@article {MurrayS48.001作者={梅丽莎·默里和Ranjan这阿什利大炮和阿曼达Liesinger欧文罗斯和罗纳德·彼得森和布拉德利Boeve和尼尔Graff-Radford和丹尼斯·迪克森},title ={焦点在海马皮质模式保留广告显示显著的临床差异(S48.001)},体积={82}={10}补充数量,elocation-id = {S48.001} ={2014},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:检查的临床相关性海马保留(HpSp) {\ textquoteright}年代老年痴呆症(广告),根据一个算法分类标识焦皮质神经元纤维缠结病理的模式。首页背景:HpSp AD患者,而典型的广告尸检发现有更高的负担在联合皮层与海马神经原纤维缠结病理,更高的频率non-amnestic临床表现和发病的年龄。设计/方法:从1821年银行我们确定了我们的大脑神经病理证实与thioflavin-S显微镜广告案例,没有证据表明海马硬化和海马和皮层神经元纤维缠结密度可用的是谁。先前描述的算法评估相对分布的海马和皮层神经原纤维缠结,187年最后一批HpSp广告案例。新算法旨在评估额叶,顶叶和颞HpSp广告模式使用皮质比率的神经原纤维缠结。结果:额的频率和性别(n = 61, 63 \ %男性),顶叶(n = 62, 59 \ %男性),和时间HpSp广告模式(n = 64, 59 \ %男性)没有差别。非典型临床诊断的额颞叶痴呆最常见的额HpSp广告(47 \ %,9/19),corticobasal综合症在顶叶HpSp广告(60 \ %,9/15)和原发性进行性失语颞HpSp广告(40 \ %,8/20)(p = 0.023)。有趣的是,认知功能障碍的发病年龄大大不同额(年龄= 59岁。)和顶叶(年龄= 61岁。),而颞HpSp广告(年龄= 69岁。)(p值< 0.001)。虽然比典型的广告短(p = 0.009),疾病持续时间没有差别在HpSp广告模式。最后,死亡年龄也发现大大不同与额叶(年龄= 70岁。)和顶叶(年龄= 69岁。),而颞HpSp广告(年龄= 78岁。)(p值< 0.001)。 CONCLUSIONS: Classification of HpSp AD neuropathologic patterns of focal cortical neurofibrillary tangle accumulation provides a unique method to improve our understanding of atypical AD patients who often pose a diagnostic conundrum. Future work will evaluate the clinicopathologic associations of early features of HpSp AD patterns to improve diagnostic accuracy. Study Supported by: AG06786, AG16574, Smith and VanBuren AD Research Program. Alzheimer{\textquoteright}s Disease Initiative, State of Florida.Disclosure: Dr. Murray has nothing to disclose. Dr. Duara has received personal compensation for activities with Pfizer Inc., Novartis, Myriad Genetics, and Martek Corp. Dr. Cannon has nothing to disclose. Dr. Liesinger has nothing to disclose. Dr. Ross has nothing to disclose. Dr. Petersen has received personal compensation for activities with Pfizer, Inc., and Janssen Alzheimer{\textquoteright}s Immunotherapy. Dr. Petersen has received royalty payments from Oxford University Press. Dr. Boeve has received research support from Cephalon, Inc., Allon Therapeutics, and GE Healthcare. Dr. Graff-Radford has received personal compensation for activities with Codman as a member of a scientific advisory board. Dr. Graff-Radford has received personal compensation in an editorial capacity for The Neurologist. Dr. Graff-Radford has received research support from Janssen, Pfizer Inc., Medivation, Forest Laboratories Inc., and Allon. Dr. Dickson has received personal compensation for activities with Neotope, Inc. as a consultant.Thursday, May 1 2014, 1:00 pm-2:45 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/82/10_Supplement/S48.001}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }