RT期刊文章SR电子T1中年偏头痛和晚期运动障碍症状:AGES-Reykjavik研究(19 - 2.001)摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯SP 19 - 2.001签证官82是10补充A1安谢尔A1 g·罗斯A首页1 Sigurdur Sigurdsson A1梅丽莎·加西亚A1 Larus Gudmundsson A1 Sigurlaug Sveinbjornsdottir A1 Vilmundur Gudnason A1 Lenore Launer年2014 UL //www.ez-admanager.com/content/82/10_Supplement/I9-2.001.abstract AB目的:确定是否患有偏头痛的中年晚年风险增加的症状帕金森病,帕金森症,和不宁腿综合症。背景:以往的研究显示,相比于那些没有,偏头痛患者有更高的铁负载在脑深部核也可能患神经条件与铁代谢的异常有关。设计/方法:AGES-Reykjavik研究是建立在以人群为基础的队列的男性和女性(b。1907 - 1935)自1967年以来。头痛症状分类(没有头痛,non-migraine头痛、偏头痛没有光环,光环(MA)和偏头痛),评估在中年时(33 - 65岁)。从2002年到2006年,5620名参与者被审查和管理问卷评估帕金森症,医生诊断为帕金森病(PD), PD的家族史,和不宁腿综合症(RLS)。考试还包括大脑核磁共振和评估心血管疾病(CVD)和风险因素。结果:那些中年偏头痛,尤其是马,在以后的生活更有可能比那些没有头痛报告四个或更多帕金森症状(ORMA = 3.6(2.7 - -4.8)),有一个诊断PD (ORMA = 2.5[1.2 - -5.2]),和满足标准(所有四个症状)RLS (ORMA = 1.5 [1.1 - -1.8])。马的女性比其他人更有可能拥有一个父(ORMA = 2.26[1.3 - -4.0])或兄弟姐妹(ORMA = 1.78[1.1 - -2.9])与PD。发现是心血管疾病独立的因素虽然我们不能排除造成头部受伤的角色。结论:这些结果表明可能有一个共同的弱点,或后果,马和运动障碍症状。 Longitudinal studies can identify candidate pathways that may account for the co-morbid constellation of symptoms. Study Supported by: NIH (N01-AG-12100), National Institute on Aging Intramural Research Program, Hjartavernd (Icelandic Heart Association), and Althingi (the Icelandic Parliament).Disclosure: Dr. Scher has received personal compensation for activities with Allergan Inc. Dr. Ross has nothing to disclose. Dr. Sigurdsson has nothing to disclose. Dr. Garcia has nothing to disclose. Dr. Gudmundsson has nothing to disclose. Dr. Sveinbjornsdottir has nothing to disclose. Dr. Gudnason has nothing to disclose. Dr. Launer has nothing to disclose.Thursday, May 1 2014, 1:00 pm-5:00 pm