PT -期刊文章盟-大卫·朱盟特蕾西Covassin AU -莎莉Nogle盟思嘉道尔非盟-罗素盟指-伦道夫·皮尔森盟-杰弗里·梦露AU -克里斯汀Liszewski盟J德马科盟——大卫·考夫曼TI -一个潜在的生物标志物在体育脑震荡:脑功能连接的改变静息状态网络测量与连续静息状态功能磁共振成像(P5.303) DP - 2014 Apr 08年TA -神经病学PG - P5.303 VI - 82 IP - 10补充4099 - //www.ez-admanager.com/content/82/10_Supplement/P5.303.short 4100 - //www.ez-admanager.com/content/82/10_Supplement/P5.303.full所以Neurology2014 Apr 08年;首页82 AB -目的:评估特定的大脑功能和结构连接生物标志物与体育运动有关的脑震荡。背景:目前的诊断和监测脑震荡的依赖症状和体征,平衡,前庭神经心理检查。传统的脑成像通常不会显示异常。最近的工作由约翰逊等人证明了静息状态网络的改变(静)静息状态功能磁共振成像(rs-fMRI) sub-acute脑震荡后阶段。设计/方法:八校际有脑震荡的运动员(20±1.3岁,一个重复的情况下)和11个对照组参与了这项研究。(立即后震荡影响评估和认知测试)过程管理的复苏。高分辨率的3 d t1, T2 *三发表和rs-fMRI图像,与整个大脑报道,从每个主题1日,收集7±1,脑震荡后30±1天。rs-fMRI包括两个7-min(闭上眼睛)回波平面图像数据集。静的相关性与关键枢纽地区,isthmi的扣带皮层(可以),在所有体素进行了分析。 RESULTS: ImPACT showed significant decline of cognitive scores across multiple categories and a significant increase of symptom score on Day 1 following a concussion, with a full recovery after 5±2.4 days. While the structural connectivity within DMN and gross anatomy appeared unchanged, a significantly reduced functional connectivity to ICCs within DMN from Day 1 to 7 was seen in the concussed group (P<0.028) , notably around anterior cingulate, medial frontal, superior frontal, middle temporal/angular and hippocampus/parahippocampal gyri. This reduction was seen in eight of our nine concussion cases. There was also a trend of improved DMN functional connectivity from Day 7 to 30. This dynamic brain alteration over one month was not seen in the normal control group. CONCLUSIONS: The functional connectivity of DMN measured with sequential rs-fMRI can potentially serve as a biomarker to monitor the dynamically changing brain function after sports-related concussion. Study Supported by:Disclosure: Dr. Zhu has nothing to disclose. Dr. Covassin has nothing to disclose. Dr. Nogle has nothing to disclose. Dr. Doyle has nothing to disclose. Dr. Russell has nothing to disclose. Dr. Pearson has nothing to disclose. Dr. Monroe has nothing to disclose. Dr. Liszewski has nothing to disclose. Dr. DeMarco has nothing to disclose. Dr. Kaufman has nothing to disclose.Wednesday, April 30 2014, 3:00 pm-6:30 pm