PT -期刊文章盟拉里萨Vilany AU - Thiago Rezende盟Luiza Piovesana AU - Lidiane Campos盟宝拉代理非盟-法比奥·托雷斯盟Marcondes语言,Jr . AU -奥古斯托。Amato-Filho盟Iscia Lopes-Cendes AU -费尔南多Cendes盟Anelyssa D 'Abreu TI -皮质评价Craniocervical肌张力障碍(P4.322) DP - 2015年4月06 TA -神经病学PG P4.322 VI - 84 IP - 14补充4099 - //www.ez-admanager.com/content/84/14_Supplement/P4.322.short 4100 -首页 //www.ez-admanager.com/content/84/14_Supplement/P4.322.full所以Neurology2015 4月06;84 AB -目的:探讨结构性变化craniocervical肌张力障碍患者使用软件Freesurfer (CCD),并探讨可能的这些领域和临床变量之间的关系。背景:craniocervical肌张力障碍的生理病理学是没有完全理解和文献提出争议关于疾病可能的结构变化。Freesurfer自动分割方法,验证在多个神经系统设置,与更好的结果比分布形态测量学,特别是皮质的措施。设计/方法:研究大学伦理委员会批准,所有受试者签署知情同意之前,任何研究相关的过程。样本由49个病人和82个对照组患者(2和3控制图像被排除在分析由于工件的原因)。我们获得T1加权像3 t磁共振扫描仪。然后我们使用Freesurfer软件获得皮层厚度、体积和皮层下。我们执行一个vertex-by-vertex探索性分析,和ANCOVA协变量的年龄、性别、和estimated-intracranial体积,纠正了Dunn-Sidak, p & lt; 0.002。此外,我们进行了一般线性模型的重要感兴趣的领域作为因变量和年龄,发病的年龄的CCD, MARSDEN_FAHN量表分数和时间与botullinum毒素作为独立的变量。 RESULTS: We found significant atrophy at the cingulate, precentral, inferior temporal and superior temporal gyrus, insula. No difference between groups was observed in subcortical analyses. Regressions showed a positive relationship between cingulate and precentral area and age of onset of dystonia. CONCLUSIONS: This study shows the involvement of motor, sensorial and limbic areas in CCD. Study Supported by: Fapesp - São Paulo Research FoundationDisclosure: Dr. Vilany has nothing to disclose. Dr. Rezende has nothing to disclose. Dr. Piovesana has nothing to disclose. Dr. Campos has nothing to disclose. Dr. Azevedo has nothing to disclose. Dr. Torres has nothing to disclose. Dr. Franca, Jr. has nothing to disclose. Dr. Amato-Filho has nothing to disclose. Dr. Lopes-Cendes has nothing to disclose. Dr. Cendes has nothing to disclose. Dr. D'Abreu has nothing to disclose.Wednesday, April 22 2015, 7:30 am-12:00 pm