TY - T1的临床和实验室因素诱发出血性转化的缺血性中风后溶栓(P6.240) JF -神经学乔-神经学六世- 84 - 14补充SP - P6.240盟Ashkan Mowla AU -哈里斯Kamal盟Peyman Shirani AU -小罗伯特·索耶盟Marilou首页 Ching AU -亚伦McMurtray AU -凯利史密斯AU - Ping Li盟萨尔曼Farooq AU -辛格Karanbir盟-艾哈迈迪AbdelRazek盟Sandhya Mehla AU - Ann Marie Crumlish盟伦敦Mehta Y1 - 2015/04/06 UR - //www.ez-admanager.com/content/84/14_Supplement/P6.240.abstract N2 -背景:与出血性转换相关的因素(HC) IV rtPa管理急性缺血性中风(AIS)仍然是模糊的。先进的年龄,署得分较高,长时间再通,头部CT早期变化和高葡萄糖水平等因素,已被证明HC静脉溶栓后的独立预测因素。本研究探讨更多的实验室和临床研究结果与HC中风病人静脉rtPA和/或动脉内的(IA)溶栓。方法:回顾性图表回顾病人的治理者IV rtPA和/或IA溶栓对AIS高容量从09/2009到04/2014进行综合中风中心。268名患者中,88例有HC指出后续成像研究,其中25 (5.5 [percnt])是基于研究所试验定义症状。除了年龄和性别等人口数据,病人的印度卢比、肌酐、白蛋白、血脂面板、血糖、糖化血红蛋白及其入学署记录和平均值HC和non-bleeders组之间的比较。t检验和逻辑回归。结果:平均年龄(p = 0.025),印度卢比(p = 0.027),署(术中;0.0001)、空腹血糖(p = 0.01)和hemoglobinA1c (p = 0.039)明显高于那些HC,而低白蛋白(术中,0.0001),低密度脂蛋白(p = 0.028)和总胆固醇(p = 0.021)与出血性转换有关。意思是肌酐和甘油三酸酯水平组之间没有显著差异。使用逻辑回归建模、高署和低白蛋白与出血性转换; where approximately 1 point increase in NIHSS or 1 mg/dL decrease in serum albumin result in about 10[percnt] and 20[percnt] increase in the risk of HC respectively. CONCLUSIONS: Based on logistic regression modeling, higher NIHSS and lower serum albumin were associated with HC in AIS patients who received IV rtPA and/or intra-arterial (IA) thrombolysis. Higher HbA1c and lower LDL levels were not found to be associated with higher risk of hemorrhagic conversion.Disclosure: Dr. Mowla has nothing to disclose. Dr. Kamal has nothing to disclose. Dr. Shirani has nothing to disclose. Dr. Sawyer has nothing to disclose. Dr. Ching has nothing to disclose. Dr. McMurtray has nothing to disclose. Dr. Smith has nothing to disclose. Dr. Li has nothing to disclose. Dr. Farooq has nothing to disclose. Dr. Singh has nothing to disclose. Dr. AbdelRazek has nothing to disclose. Dr. Mehla has nothing to disclose. Dr. Crumlish has nothing to disclose. Dr. Mehta has received personal compensation for activities with Biogen Idec, Teva Neuroscience, and the Gerson Lehrman Group as a as a speaker and/or consultant.Thursday, April 23 2015, 7:30 am-12:00 pm ER -