作者@article {ParkP4.256 ={汉娜公园和朱莉·罗斯},title ={吸入大麻对cEEG峰值计数的影响在一个33岁的男人与特发性癫痫:一个案例报告(P4.256)},体积={84}={14}补充数量,elocation-id = {P4.256} ={2015},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:尽管增加临床证据支持大麻衍生物作为有前途的抗癫痫药物,客观的标志物是一个缺乏。首页背景:我们报告一个病人难治性癫痫,对待levetiracetam神经和迷走神经刺激(VNS),其峰值依靠连续脑电图监测(cEEG)与吸入吸食大麻。设计/方法:一个33岁的男人与广义tonic-clonic发作了17年报道经历更少的癫痫吸入休闲大麻。他寻求外科检查失败后大量的抗惊厥药物。连续脑电图(cEEG)进行共11天。结果:初始动态cEEG (levetiracetam,迷走神经刺激法,和娱乐大麻使用)显示间歇性左颞放缓与罕见的尖锐形式但没有棘波放电/ 3天。住院病人住院发生两个月后;病人奉命停止吸食大麻入学前至少一个星期。与治疗的否则,cEEG复发性广义和左额棘波放电,平均29日峰值/ 10分钟时代(范围:0 - 179),通过levetiracetam锥度与类似的范围和VNS关闭天2 - 4。癫痫发生在第四天。 Ambulatory cEEG continued after discharge; the patient was instructed to avoid marijuana use until day 6. Between days 7 and 8, spikes diminished, and 0 spikes occurred in the last 12 hours of cEEG. MRI was normal, and FDG-PET demonstrated left hemisphere reduced uptake. CONCLUSIONS: We report a patient with refractory, idiopathic epilepsy with subjective seizure improvement on marijuana, corroborated by a lack of spike-wave discharges on cEEG while using the substance,dramatic appearance of spike-waves after marijuana cessation for one week, and spike suppression again noted following resumed home marijuana use. While spike count is not a surrogate marker for seizure control, it nonetheless represents an objective biomarker of abnormal neural activity, and may provide a window into mechanism of action. Study Supported by: Rhode Island HospitalDisclosure: Dr. Park has nothing to disclose. Dr. Roth has nothing to disclose.Wednesday, April 22 2015, 7:30 am-12:00 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/84/14_Supplement/P4.256}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }