TY -的T1 -非症状患者SPG4突变(P7.191) JF -神经学乔-神经学六世- 84 - 14补充SP - P7.191盟Katiane Servel首页here AU -乔纳斯炒盟阿德里亚娜莫罗AU -阿尔贝托·马丁内斯盟英格丽德Vasconcellos AU -劳拉Jardim盟赫利奥阿方索Teive AU - Iscia Lopes-Cendes AU - Anelyssa D´阿伯盟Marcondes语言,Jr . Y1 - 2015/04/06 UR - //www.ez-admanager.com/content/84/14_Supplement/P7.191.abstract N2 -目的:评估在SPG4-HSP非症状的频率和严重程度,尤其是疲劳、疼痛、抑郁和日间极度嗜睡。背景:SPG4基因的突变是最常见的遗传性痉挛性截瘫原因(HSP)。SPG4-HSP特点是缓慢渐进痉挛状态和软弱的腿。额外的非症状在偶尔SPG4-HSP患者已报告,但没有这样的表现已经完成的系统评价。设计/方法:患者27分子确认SPG4-HSP从3中心在巴西南部和26岁和sex-matched健康对照组回答修改后的疲劳影响规模(小额信贷机构),埃普沃思嗜睡量表(ESS)、血管(视觉模拟的规模)和贝克抑郁(BDI)库存。痉挛性截瘫评定量表(spr)被用来量化疾病严重程度。我们学生的学习任务比较组和皮尔森系数调查可能的临床参数之间的相关性。P值& lt; 0.05被认为是重要的。结果:患者的平均年龄为48.0±13.8岁,意味着spr得分为19.5±11.6,有16人。比控制SPG4-HSP患者有更严重的疲劳(小额信贷机构:31.3±14.9 vs 14.9±15.4,术中;0.001)。 Physical and psychosocial subscores of MFIS were higher in the patient group (p<0.001), but not cognitive subscores (p=0.98). Mean VAS score was significantly higher among patients (2.6±2.08 vs 1.1±2.0, p=0.02). Depressive symptoms were more severe among patients (12.5±8.9 vs 4.3±4.0, p<0.001), but even in this group scores were not remarkable. There was no difference between groups regarding daytime sleepiness (p=0.77). Motor disability presented a correlation with fatigue (r=0.385, p=0.04) but not with pain (p=0.267). Conclusions: Fatigue and pain are frequent manifestations in SPG4-HSP. They are often severe, and at least in part, explained by the motor disability. Neurologists should actively investigate and treat these non-motor manifestations.Disclosure: I receive CAPES Dr. Saute has nothing to disclose. Dr. Moro has nothing to disclose. Dr. Martinez has nothing to disclose. Dr. De Vasconcellos has nothing to disclose. Dr. Jardim has nothing to disclose. Dr. Teive has nothing to disclose. Dr. Lopes-Cendes has nothing to disclose. Dr. D´Abreu has nothing to disclose. Dr. Franca, Jr. has nothing to disclose.Thursday, April 23 2015, 2:00 pm-6:30 pm ER -