RT期刊文章SR电子T1视网膜微血管迹象和年龄相关性黄斑变性与事件相关脑Microbleeds根据老年人的位置:AGES-Reykjavik研究(S45.005)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP S45.005 VO 84 14补充A1杰丁A1 Chengxuan邱A1 Sigurdur Sigurdsson A1张倩A1 Gudny Eiriksdottir A1 Vilmundur Gudnas首页on A1马克•范Buchem A1玛丽弗朗西斯Cotch A1 Lenore Launer年2015 UL //www.ez-admanager.com/content/84/14_Supplement/S45.005.abstract AB目的:调查是否视网膜微血管迹象和年龄相关性黄斑变性(AMD)与事件相关脑Microbleeds (CMBs)根据不同的位置。背景:CMBs造成高血压主要是位于深半球或infratentorial位置,而从脑淀粉样血管病是叶的地区。之间存在相当大的同源性视网膜和大脑微循环和amyloid-β存款涉及后期AMD的发病机理。方法:前瞻性,以人群为基础的AGES-Reykjavik研究,66 - 93岁的2506名参与者进行了基线大脑MRI检查和双眼视网膜数码摄影在2002 - 2006年,并在2007年返回重复的大脑核磁共振- 2011。视网膜微血管迹象(焦小动脉的狭窄,动静脉轻伤,微动脉瘤/出血)和AMD,以及CMBs分级标准化协议。逻辑回归应用于与视网膜唱CMBs发病率。结果:在一个平均5.2年的随访中,463人(18.5 [percnt])开发新的CMBs,其中169已经CMBs深地区和294年CMBs局限于叶的地区。在调整了年龄和性别,视网膜微血管唱在发展中深CMBs可能性显著增加(优势比[或]焦点缩小2.51 [95 (percnt)置信区间1.42 - -4.42),动静脉轻伤2.19(1.54 - -3.12),微动脉瘤/出血1.75[1.17 - -2.60])但不是叶的CMBs。纯地理AMD的人更容易患上严格肺叶的CMBs 2.50(1.02 - -6.11),但不深CMBs。当进一步调整血管危险因素包括血压、基线CMBs,皮层下梗死和白质hyperintensities,这些协会坚持除了微动脉瘤/出血,成为边缘显著(p = 0.063)。 CONCLUSIONS:Retinal arteriolar signs attributable to high blood pressure were associated with incident deep CMBs and late geographic AMD was associated with strictly lobar CMBs. Our findings suggest specific markers of retina may aid in identifying older people at high risk of developing CMBs in different regions.Disclosure: Dr. Ding has nothing to disclose. Dr. Qiu has nothing to disclose. Dr. Sigurdsson has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Eiriksdottir has nothing to disclose. Dr. Gudnason has nothing to disclose. Dr. Van Buchem has nothing to disclose. Dr. Cotch has nothing to disclose. Dr. Launer has nothing to disclose.Thursday, April 23 2015, 1:00 pm-2:45 pm