RT期刊文章SR电子T1患者痴呆的神经病理学和Non-Dementia长寿老人的乔(P2.176)摩根富林明神经病学神经病学FD Lippincott Williams &威尔金斯SP P2.176 VO 84 14补充A1 Gamze Balci Cam首页sari A1尼尔Graff-Radford A1罗纳德·彼得森A1 David Knopman A1布拉德利Boeve A1约瑟夫·帕里A1丹尼斯·迪克森A1梅丽莎·默里年2015 UL //www.ez-admanager.com/content/84/14_Supplement/P2.176.abstract AB目的:更好地定义非痴呆的神经病理学和精神错乱的人死亡> 95年背景:神经退行性疾病的研究都集中在younger-old尽管长寿老人的人口显著增长。临床和神经病理特征的神经退化似乎在不同的年龄有很大的不同。长寿老人的,神经病理结果与认知障碍之间的相关性是不完美的,这可能与未知的机制和/或多个病态的相伴。设计/方法:大脑和临床记录137解剖学科痴呆(n = 71)和非痴呆(n = 66,包括轻度认知障碍)的95岁及以上的人死亡时间进行了研究。标准的神经病理技术被用来确定病理的类型和严重性。结果:死亡年龄,教育和性没有非痴呆和精神错乱的人之间的差异。APOEε4运营商在非痴呆组未被充分代表的,但这并没有意义。阿尔茨海默氏症病理类型显著不同群体之间,有趣的是弥散斑的严重程度在皮层没有差别。血管疾病非痴呆组明显不太常见,但海马硬化的存在,路易的身体疾病,argyrophilic谷物疾病没有差别。共存的神经病理学与(我没有明显不同。e, normal pathologic diagnosis) being less frequent in the non-demented cohort and three or more neuropathologies being more frequent in the demented cohort. CONCLUSIONS: 1.Age, gender and education do not differ significantly in dementia and non-dementia groups.2. Subjects with clinical dementia commonly (80[percnt]) demonstrate Alzheimer's pathologic features and frequently have coexisting neurodegenerative and vascular disease(s).3.Those without clinical dementia frequently have degenerative neuropathology including plaques (66[percnt]), hippocampal sclerosis 8[percnt], vascular disease (38[percnt]) Lewy Bodies (25[percnt]) and argyrophilic grain pathology (23[percnt]). Only 34[percnt] had no plaques. 4. Apoε4 was more frequent in the dementia and Apoε2 in the non-dementia group but neither was significant.Disclosure: Dr. BALCI CAMSARI has nothing to disclose. Dr. Graff-Radford has received personal compensation for activities with Codman and Cytox as a scientific advisory board member or a consultant. Dr. Graff-Radford has received royalty payments for UpToDate. Dr. Petersen has received personal compensation for activities with Pfizer Inc. and Janssen Alzheimer's Immunotherapy. Neurology, Deputy Editor, Dr. Boeve has received research support from GE Healthcare. Dr. Parisi has nothing to disclose. Dr. Dickson has nothing to disclose. Dr. Murray has nothing to disclose.Tuesday, April 21 2015, 7:30 am-12:00 pm