@article {SandnessP7.307作者={大卫Sandness Erik圣路易斯和斯图尔特McCarter布拉德利Boeve和迈克尔·西尔柏},title = {REM睡眠没有弛缓严重性预测认知障碍在REM睡眠行为障碍(P7.307)},体积={84}={14}补充数量,elocation-id = {P7.307} ={2015},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们研究快速眼动睡眠是否没有弛缓(RSWA)严重程度与认知功能在REM睡眠行为障碍(RBD)。首页背景:RBD是一个潜在的有害深眠状态,与synucleinopathy密切相关。RBD患者展览RSWA,失去正常的肌肉弛缓在REM睡眠期间,在多导睡眠图(PSG)。设计/方法:特发性(iRBD)和RBD症状(睡眠相关)患者完成两个认知电池:中枢神经系统体征(CNS-VS)和有用的视野(UFOV)。所有的受试者都接受PSG和肌肉(SM: submentalis;:前胫骨)语气在REM睡眠是视觉并自动得分。睡眠相关组差异和iRBD然后比较,和回归模型来确定RSWA和依赖认知措施之间的关系。结果:20 iRBD和10睡眠相关参与。人口统计群体之间是相似的。赤字在认知测试观察在处理(睡眠相关\ < CNS-VS iRBD, p = 0.014)和精神运动速度(sRDB \ < iRBD, p = 0.019)和总UFOV和单项成绩2和3(睡眠相关\ > iRBD, p < 0.002)。 sRBD patients had greater combined phasic and tonic RSWA in SM (p=0.026) and longer mean phasic burst duration (p=0.03). Regression analyses demonstrated that SM RSWA independently predicted overall CNS-VS Neurocognitive Index (NCI) (F=4.5, p=0.006), adjusting for age, gender, depressive symptoms (Zung Score), and sleep disturbances (PSQI), and this relationship also remained significant for the iRBD group after excluding sRBD patients from analysis to account for the effect of co-morbid neurologic or cognitive disorders (F=3.5, p=0.03). SM RSWA was not predictive of total UFOV performance. CONCLUSIONS: RSWA is predictive of lower overall cognitive performance in patients with RBD. Future prospective analysis of a larger cohort is planned to determine whether RSWA may also predict other neurological signs of phenoconversion to overt synucleinopathy in iRBD patients. Study Supported by: UL1 RR024150-01.Disclosure: Dr. Sandness has nothing to disclose. Dr. St. Louis has received personal compensation for activities with Inspire, Inc. Dr. McCarter has nothing to disclose. Dr. Boeve has received research support from GE Healthcare. Dr. Silber has nothing to disclose.Thursday, April 23 2015, 2:00 pm-6:30 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/84/14_Supplement/P7.307}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }