@article {HaightP1.088作者={撒迪厄斯海特和尼克·布莱恩和Guray Erus Christos Davatzikos和大卫·雅各布斯和马克D {\ textquoteright}埃斯波西托和科拉刘易斯和Lenore Launer}, title ={高血压、脑血管反应性和大脑静息状态网络:发现冠状动脉风险发展的年轻人(贲门)大脑MRI∶(P1.088)},体积={84}={14}补充数量,elocation-id = {P1.088} ={2015},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:检查脑血管反应性(表格)的大脑区域的静息状态网络(静)有无高血压。首页背景:脑功能降低,形态学改变之前被检测到,可能代表一个标记在后期生活对大脑功能障碍。减少表格在一个或多个静地区可能是中断的网络个人在中年高血压。设计/方法:受试者541名男性和女性(平均年龄50.4岁,标准差3.5)接受了屏息功能磁共振成像。表格被量化为百分比变化在血氧水平依赖(BOLD)信号激活体素,这是映射到一个共同的大脑模板和对数转换。表格是计算出解剖区域的静,除了枕叶,用作参考。美国心脏协会的指导方针被用来分类科目为高血压前期/高血压和血压正常的人。模型评估意味着表格在大脑区域包括静,枕叶相比,血压状态。结果:表格是静地区相对较低意味着表格在枕叶科目吗/高血压和血压正常的受试者相比,尤其是后扣带/楔前叶(β= -0.072,95 [percnt] CI: -0.115, -0.029)和前扣带(β= -0.059,95 [percnt] CI: -0.104, -0.014)。相比之下,表格是低,但不显著,在内侧额叶(β= -0.039,95 [percnt] CI: -0.080, 0.003),下顶叶(β= -0.029,95 [percnt] CI: -0.067, 0.009)和海马体(β= -0.022,95 [percnt] CI: -0.077, 0.034)。 Findings for the posterior cingulate/precuneus and anterior cingulate were attenuated but remained significant after adjustment for age, race, sex, smoking status, and ApoE4 genotype status. CONCLUSIONS:Reduced CVR may represent diminished vascular functionality for the DMN for individuals with prehypertension/hypertension in mid-life, and may serve as a preclinical marker for future brain changes.Disclosure: Dr. Haight has nothing to disclose. Dr. Bryan has nothing to disclose. Dr. Erus has nothing to disclose. Dr. Davatzikos has nothing to disclose. Dr. Jacobs has nothing to disclose. Dr. D{\textquoteright}Esposito has nothing to disclose. Dr. Lewis has received research support from Novo Nordisk. Dr. Launer has nothing to disclose.Monday, April 20 2015, 2:00 pm-6:30 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/84/14_Supplement/P1.088}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }