@article {MatosP02.217作者={亚历山大·马托斯和蒂亚戈Peluzzo和维尼Pascoal和Rovilson Gilioli和Iscia Lopes-Cendes}, title = {MicroRNA管制涉及毛果芸香碱诱导癫痫模型中的小胶质激活(P02.217)},体积={80}={7}补充数量,页面= {P02.217——P02.217} ={2013},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:本研究的目的是分析mir - 124的表达的急性期毛果芸香碱癫痫模型。首页因此,调查是否异常的小胶质激活,通常观察到在这个模型中,可以由微rna放松管制。背景:小分子核糖核酸调节基因的表达等许多重要的生物功能,是重要的发展,肿瘤形成和炎症。一微,mir - 124,是表达只在中枢神经系统,涉及维护小胶质细胞在非活性或静止状态。众所周知,活化的小胶质细胞必须正确、严格监管维护正常组织内稳态,避免组织损伤。设计/方法:我们获得的总RNA从动物的海马1、3、6和24小时,以及诱导后5天的癫痫持续状态(SE)和控制动物。我们量化表达式定量实时PCR的mir - 124。只老鼠组织获得了SE是用于我们的实验。结果:我们发现mir - 124的表达显著减少后,大约60 \ %,相比,控制样品。mir - 124表达下降已经在1 h后SE和保持在低位,直到5天后。CONCLUSIONS: Our results indicate that regulation by microRNA, especially by miR-124, can play a role in microglia activation after SE induced by pilocarpine. Thus, opening the possibility of using microRNA-based therapies in epilepsy.Supported by: FAPESP.Disclosure: Dr. Matos has nothing to disclose. Dr. Peluzzo has nothing to disclose. Dr. Pascoal has nothing to disclose. Dr. Gilioli has nothing to disclose. Dr. Lopes-Cendes has nothing to disclose.Tuesday, March 19 2013, 7:30 am-12:00 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/80/7_Supplement/P02.217}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }