% 0期刊文章%一个玫瑰花蕾罗伯茨%米歇尔Mielke %露丝Cha %一个David Knopman弗农Pankratz说道% % % Yonas Geda布拉德利Boeve %一个Kejal Kantarci %沃尔特·罗卡% Clifford杰克%罗纳德·彼得森% Val劳% T糖尿病是与全球和区域相关代谢减退的老年人中:梅奥诊所的研究衰老(P07.137) % D J神经病学2013% % P P07.137-P07.137 % V 80% N % X 7补充目的:调查的横断面糖尿病协会与淀粉积累用11 c-pittsburgh复合B(加以)和脑代谢减退测量使用18 f-fluorodeoxyglucose (FDG正电子发射断层扫描)。首页背景:2型糖尿病与脑萎缩有关,轻度认知障碍,阿尔茨海默病(AD)和血管性痴呆,可能通过血管机制。一些神经病理学研究表明糖尿病患者更大的斑块病理。对体内的淀粉积累和代谢减退不建立的标志。设计/方法:我们研究了奥姆斯特德县的人口基数,MN居民在诊断类别(认知正常、轻度认知障碍、痴呆)。PET图像获得使用PET / CT扫描仪。摄影图像得到1小时后加以扫描;糖尿病受试者正常的血糖水平。在3 t MRI进行3 d-mprage序列。全球和地区感兴趣的措施。糖尿病是使用罗彻斯特流行病学项目医疗records-linkage系统决定的。RESULTS: Among 760 participants (median age 79 years), FDG ratio was lower in diabetics (n=160) than in non-diabetics (n = 601) for global FDG (1.575 vs. 1.620; p = 0.003), and in posterior cingulate/precuneus (1.752 vs. 1.812, p < 0.001), parietal (1.748 vs. 1.819, p = 0.002), temporal (1.488 vs. 1.519, p = 0.011), and prefrontal (1.727 vs. 1.785, p < 0.002) regions. However, the global PIB ratio did not differ in diabetics vs. non-diabetics (1.40 vs. 1.39; p = 0.43).CONCLUSIONS: Diabetes was associated with lower FDG ratios globally and in regions that are among those thought to be key in AD. Our findings suggest that diabetes has a non-vascular role in the pathogenesis of AD.Supported by: U01 AG006786, P50 AG016574, K01 AG028573, K01 MH68351, R01 AG034676, AG011378, K01 MH68351, R01 AG040042, R01 AG034676, Robert H. and Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program. Center for Individualized Medicine of Mayo Clinic, Minnesota Partnership for Biotechnology and Medical Genomics, GE Health Care, The Elsie and Marvin Dekelboum Family Foundation.Disclosure: Dr. Roberts has received research support from Abbott Laboratories. Dr. Mielke has nothing to disclose. Dr. Cha has nothing to disclose. Dr. Pankratz received financial support for research activities from Abbott Laboratories. Dr. Knopman has received personal compensation for activities with Eli Lilly & Company. Dr. Knopman has received personal compensation in an editorial capacity for Neurology. Dr. Knopman has received research support from TauRx. Dr. Geda has nothing to disclose. Dr. Boeve has received research support from Cephalon, Inc.; Allon Therapeutics; and GE Healthcare. Dr. Kantarci has received compensation from Takeda Global Research & Development Center for serving as an advisory board member for research support. Dr. Rocca has nothing to disclose. Dr. Jack has received personal compensation for activities with Janssen, Eisai Inc., General Electric, Johnson & Johnson, and Eli Lilly & Company. Dr. Jack has received research support from Pfizer Inc, Allon, and Baxter. Dr. Jack has received research support from Allon and Baxter. Dr. Petersen has received personal compensation for activities with Pfizer, Inc., Janssen Alzheimer's Immunotherapy, Elan Pharmaceuticals, GE Healthcare, and Novartis. Dr. Lowe received personal compensation for consulting from Bayer Pharmaceuticals. Dr. Lowe received research grants from GE Health Care, Siemens Molecular Imaging, and AVID Radiopharmaceuticals, Inc.Thursday, March 21 2013, 2:00 pm-7:00 pm %U

map