@article {CarmichaelPD1.002作者={欧文卡迈克尔和京谢Baljeet辛格和埃文·弗莱彻和Charles DeCarli}, title ={基线CSF淀粉样蛋白和τ与海马局部变化有关独立的海马体总额(PD1.002)},体积={78}={1}补充数量,页面= {PD1.002——PD1.002} ={2012},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:探讨基线指标之间的关联{\ textquoteright}年代老年痴呆症(广告)的病理学和spatially-localized测量后续纵向海马萎缩。首页提出模型的背景广告,提升大脑淀粉样蛋白和磷酸化τ负担导致后续在海马神经元死亡和其他地区。然而,报道称,体内淀粉样蛋白和τ之间的关系,并从MRI海马总额,不一致。因为海马损伤广告遵循典型的空间发展,海马体的局部措施改变可能是更敏感的广告效果。设计/方法:168 {\ textquoteright}年代老年痴呆症神经影像倡议参与者(48正常,73 MCI, 47个广告)收到大脑核磁共振在基线和为期一年的随访,随着基线测量淀粉样,总τ,磷酸化τ(p-tau)脑脊液(CSF)。海马体是划定半自动生成使用验证软件例程从核磁共振(手术导航技术)。相应的基线和随访海马表面一致,局部萎缩率估计为单独的表面点。海马局部成分分析(轨迹)总结整个人口的spatially-localized改变模式。线性回归模型使用基线CSF措施,年龄,性别,和多年的教育预测的本地化率海马萎缩,所总结的轨迹,和总海马体积。海马体总额是一个额外的预测模型局部萎缩。结果:基线总τ和磷酸化τ负担,和较小的基线淀粉样负担,与速度有关局部身体侧海马萎缩,大致对应于CA1分场优先破坏广告(每个p \ < .005)。 However, baseline amyloid, but not tau or p-tau, were associated with rate of total hippocampus volume change (each p\<.007).Conclusions: Localized hippocampus change measures may be more strongly associated with AD-related pathology than total hippocampus volume change is.Supported by: Dana Foundation, NIH U01 AG024904, P30 AG010129, K01 AG 030514.Disclosure: Dr. Carmichael has nothing to disclose. Dr. Xie has nothing to disclose. Dr. Singh has nothing to disclose. Dr. Fletcher has received personal compensation for activities with Unilever. Dr. DeCarli has received personal compensation for activities wtih Merck Pharmaceutical, Avanir, Bayer Pharmaceuticals, and Pfizer as a consultant.Dr. DeCarli has received personal compensation in an editorial capacity for Alzheimer{\textquoteright}s Disease and Associated Disorders.Dr. DeCarli has received research support from Merck.Monday, April 23 2012, 14:00 pm-18:30 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/78/1_Supplement/PD1.002}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }