@article {RazS29.007作者= {Limor拉兹和Jayachandran Muthuvel和Nirubol Tosakulwong和蒂姆Lesnick和玛丽塔Dowling惠特尼·沃顿和凯里格里森Samentha威利和马修·墨菲和马修Senjem Prashanthi Vemuri和克利福德杰克和格伦·史密斯和桑杰就是为了和弗吉尼亚米勒和Kejal Kantarci}, title ={白质Hyperintensities最近更年期妇女与血小板源代理标记相关联的心血管风险(S29.007)},体积={80}={7}补充数量,页面= {S29.007——S29.007} ={2013},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:确定之间的关系白质Hyperintensities(负责人)FLAIR-MRI和传统(如血压、体重指数、血脂、空腹血糖水平)非常规的心血管风险因素(CV) {\ textquotedblleft}外围血管内舱{\ textquotedblright}[即。首页血小板激活,pro-thrombotic微泡(MV)]和认知功能。背景:在老年人,负责人增加随着年龄的增长,与轻度认知障碍和中风的风险增加。然而,这些年轻的关系,健康的人不清楚。设计/方法:最近更年期妇女(n = 95)与中值(范围)53岁(45-58)参加科隆诺斯早期雌激素预防研究(保持)梅奥诊所参与成像亚组。半自动算法被用来量化研究负责人前(基线),18岁,36,随机化激素治疗后48个月。基线研究负责人负载和负责人卷在48个月的变化与常规和非常规CV风险因素在基线和认知功能的变化在48个月。调整了年龄,绝经时间过去,ApoEε4运用多元线性回归模型进行整个组的主题。结果:在基线,没有负责人和传统心血管危险因素之间的相关性被发现。然而,血小板活化以纤维蛋白原受体的表达(糖蛋白Iib / iii a复杂衡量PAC1绑定)与基线研究负责人卷(p = 0.04)。在48个月,负责人卷从基线增加(中位数(差)= 359.6 (205、568)mm3)。 Increases in WMH correlated with the number of baseline platelet-derived and thrombogenic MV (p=0.03). Changes in WMH volume did not correlate with changes in cognitive function over 48 months.CONCLUSIONS: Activated platelets and thrombogenic MV as surrogate markers of cardiovascular risk contribute to progression of WMH. Increases in WMH do not appear to impact cognitive performance in this healthy cohort of recently menopausal women.Supported by: Aurora Fund, HL90639, NS066147, HD65987, AG029624, Mayo Foundation.Disclosure: Dr. Raz has nothing to disclose. Dr. Muthuvel has nothing to disclose. Dr. Tosakulwong has nothing to disclose. Dr. Lesnick has received personal compensation for activities with Reproductive Medicine and Infertility Associates as a consultant. Dr. Dowling has nothing to disclose. Dr. Wharton has nothing to disclose. Dr. Gleason has nothing to disclose. Dr. Wille has nothing to disclose. Dr. Murphy has nothing to disclose. Dr. Senjem has nothing to disclose. Dr. Vemuri has nothing to disclose. Dr. Jack has received personal compensation for activities with Janssen, Eisai Inc., General Electric, Johnson \& Johnson, and Eli Lilly \& Company. Dr. Jack has received research support from Pfizer Inc, Allon, and Baxter. Dr. Jack has received research support from Allon and Baxter. Dr. Smith has nothing to disclose. Dr. Asthana served as a site PI for industry-funded clinical trials in Alzheimer{\textquoteright}s disease. Dr. Miller has nothing to disclose. Dr. Kantarci has received compensation from Takeda Global Research \& Development Center for serving as an advisory board member for research support.Wednesday, March 20 2013, 2:00 pm-3:45 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/80/7_Supplement/S29.007}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }