% 0期刊文章%一个扎卡里·米勒%凯瑟琳·兰金%玛丽亚·路易萨%玛雅亨利%的铜质把手一个斯蒂芬·威尔逊%米兰达Babiak %一个Bettcher Brianne Darvis弗雷泽% %一个吴特蕾莎修女%的派遣块%罗宾Ketelle %一个克里斯汀Heggeli肯·爱德华兹% %霍华德·罗森%一个吉尔Rabinovici乔尔·克雷默% %尼尔Graff-Radford %一个威廉·布鲁斯·米勒斯利% %玛丽亚Gorno Tempini % T手偏好和学习障碍不同分发PPA变体(P03.093) % D J神经病学2013% % P P03.093-P03.093 % V 80% N % X 7补充目的:描述偏手性的发育特征和语言学习障碍在原发性进行性失语。首页背景:原发性进行性失语由3变种- logopenic、迟滞型和语义。每个子类型与不同的解剖参与和通常用离散潜在的病理。之前文学发展的PPA表明与神经发育相关证明学习障碍的增加率在PPA患者和2例左hemicranial发育不全在PPA语义变体。设计/方法:我们筛选UCSF记忆和衰老中心的PPA队列手偏好和LD的历史。这项研究包括logopenic变体PPA (lvPPA), n = 47;迟滞型变体PPA (nfvPPA), n = 54;语义变体(svPPA), n = 96。svPPA的独立样本,n = 36岁的梅奥诊所提供的杰克逊维尔和PSP, n = 107,来自加州大学旧金山分校是专为偏手性筛查。结果:有近两倍的患病率nRH svPPA队列,在nfvPPA nRH患病率的一半,nRH符合lvPPA偏手性一般人群。这些构型的研究结果证实了我们的独立组织。lvPPA组有更大的可能性LD相比svPPA和nfvPPA组。lvPPA集团LD患者年轻和内增加了全球功能比lvPPA没有LD.CONCLUSIONS表示:一个独特的模式的偏好和历史的语言学习障碍似乎与每个亚型PPA强烈相关。 This further strengthens previous findings in PPA and may provide new insights into how neurodevelopment affects neurodegenerative disease susceptibility.Supported by: National Institutes of Health (grants P01 AG19724, P50 AG023501, P50 AG1657303, P50AG16574, R01-AG032306, and R01 NS050915-05A1) and its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institute on Aging or NIH. Additional funds include the Consortium for Frontotemporal Dementia Research, the NSF Graduate Research Fellowship, and the Tau Research Consortium.Disclosure: Dr. Miller has nothing to disclose. Dr. Rankin has nothing to disclose. Dr. Mandelli has nothing to disclose. Dr. Henry has nothing to disclose. Dr. Wilson has nothing to disclose. Dr. Babiak has nothing to disclose. Dr. Frazier has nothing to disclose. Dr. Bettcher has nothing to disclose. Dr. Wu has nothing to disclose. Dr. Block has nothing to disclose. Dr. Ketelle has nothing to disclose. Dr. Edwards has nothing to disclose. Dr. Heggeli has nothing to disclose. Dr. Rosen has nothing to disclose. Dr. Kramer has nothing to disclose. Dr. Rabinovici has received personal compensation for activities with Eli Lilly & Company......Dr. Rabinovici has received research support from Avid Radiopharmaceuticals and Eli Lilly & Company. Dr. Graff-Radford has received personal compensation for activities with Codman. Dr. Graff-Radford has received personal compensation in an editorial capacity for the Neurologist. Dr. Graff-Radford has received research support from Janssen, Pfizer Pharmaceuticals, Medivation, Forrest, and Allon. Dr. Seeley has received personal compensation for activities with Korea Novartis, Summer Street Research Partners and Bristol-Myers Squibb for speaker, consulting and scientific advisory boards. Dr. Miller has received personal compensation for activities with Allon Therapeuctics, Inc. and TauRx Therapeutics, Ltd. Dr. Miller has received research support from Novartis. Dr. Gorno Tempini has nothing to disclose.Tuesday, March 19 2013, 2:00 pm-6:30 pm %U