TY - T1的主要进步言语失用症(PAS):一个独特的神经退行性综合征(P07.167) JF -神经学乔-神经病学SP - P07.167 LP - P07.167六世- 78 - 1补充AU -基思·约瑟夫盟埃德斯-站-首页约瑟夫·达菲盟盟-玛丽Machulda AU -马修Senjem盟Ankit欧大师- Val劳盟-克利福德杰克盟-珍妮弗Whitwell Y1 - 2012/04/26 UR - //www.ez-admanager.com/content/78/1_Supplement/P07.167.abstract N2 -目的:确定言语失用症(代谢)可以作为一个孤立的神经退行性疾病的标志,如果是这样的话,确定这种综合症的定义特征。背景失用症的演讲是演讲的障碍运动规划和/或编程的失语和构音障碍。它可以发生在退化性疾病,它通常被归入失语症,或者在更广泛的神经退化。设计/方法:超过1年,37例退行性神经语言障碍是前瞻性招募,并进行了详细的演讲和语言,神经,神经心理学和神经成像测试,包括3.0 Telsa体积MRI,弥散张量成像,18 f氟脱氧葡萄糖(FDG)和C11加以PET扫描。结果:37的主题,我们确定了12个市场没有失语。这12个受试者主要进步先进(PAS)包括8妇女。平均发病年龄为73岁(范围:49 - 82)。基于体素的形态测量学(VBM)灰质显示焦点失去优越的侧前运动皮层和补充运动区。VBM的白质体积显示这些地区的损失与扩展损失胼胝体的劣质前运动皮层和身体。这些区域的白质损失与tract-based空间统计观察,证明减少分数各向异性和上纵束的平均扩散系数增加,特别是运动组件。SPM分析正子扫描显示焦点代谢减退优越的侧前运动皮层和辅助运动区,虽然有一些变化在各个科目。C11 PiB-PET绑定是增加一个主题,尽管目前尚不清楚的增加实际上是不相关的。Conclusions: A syndrome of pure apraxia of speech clearly exists, with a neuroanatomic correlate of superior lateral premotor and supplementary motor atrophy, making this syndrome distinct from primary progressive aphasia.Supported by: NIH grants R01 DC010367 and R01 AG 11378.Disclosure: Dr. Josephs has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. Strand has nothing to disclose. Dr. Machulda has nothing to disclose. Dr. Senjem has nothing to disclose. Dr. Master has nothing to disclose. Dr. Lowe has nothing to disclose. Dr. Jack has received personal compensation for activities with Janssen Pharmaceutica, Eisai Inc, General Electric, Johnson and Johnson, and Eli Lilly & Company as a consultant.Dr. Jack has received research support from Pfizer Inc, Allon, and Baxter, Inc. Dr. Whitwell has nothing to disclose.Thursday, April 26 2012, 14:00 pm-18:30 pm ER -