TY - T1的系统回顾的慢性脑脊髓静脉功能不全和多发性硬化症之间的联系(P05.126) JF -神经学乔-神经病学SP - P05.126 LP - P05.126六世- 78 - 1补充Andreas Laupacis AU -朱迪·伯顿盟盟——艾琳·莉莉·盟——安德鲁Dueck首页 Laure毕雷矿泉水AU -莎朗·施特劳斯盟盟-理查德特拉维夫盟凯文·索普AU -托马斯Feasby盟朱利安长矛Y1 - 2012/04/25 UR - //www.ez-admanager.com/content/78/1_Supplement/P05.126.abstract N2 -目的:本系统评价进行检查的证据之间的关联慢性脑脊髓静脉功能不全(CCSVI)和多发性硬化症(MS)使用严谨的方法论的分析。背景提出的,女士是由超声波检测到异常的解剖学和流动,extra-cerebral静脉内,一个条件称为CCSVI。设计/方法:奥维德的文献检索MEDLINE,科克伦中央的对照试验和EMBASE进行登记。合格的研究使用超声诊断CCSVI和比较医学患者与健康对照组(HC)和/或其他神经系统疾病患者(的生命)。随机效应模型使用和优势比(或)和I2值生成。结果:8个研究相比CCSVI MS患者和HC的频率;4研究相比与女士的生命。女士CCSVI诊断更为普遍和HC(或13.5,p = 0.002),但显著的异质性在这种联系的频率和大小。具有统计学意义,但减少协会仍然使用最保守的分析(或3.4,p = 0.02),涉及删除Zamboni的最初研究和添加一个负面CCSVI研究。研究比较和女士的生命还发现CCSVI女士更常见,但这不是统计学意义(或32.5,p = 0.09)。或降至3.4 (p = 0.11),去除Zamboni的研究。没有研究报道致盲的测试技术员或放射科医生。结论:这个系统回顾并找到一个显著更大几率CCSVI的MS患者和HC,但不是在与女士的生命。 Limitations including uncertainty regarding blinding and marked heterogeneity of the results, and do not allow for definitive conclusions. These early results raise the possibility that CCSVI may not be MS-specific, and it may follow, not precede onset of disease. Further high quality controlled studies are needed to definitively determine if CCSVI is truly associated with MS.Supported by: A grant from the Canadian Institutes of Health Research (CIHR).Disclosure: Dr. Burton has received personal compensation for activities with Biogen Idec and Novartis. Dr. Laupacis has received personal compensation for activities with Novartis Pharmaceuticals, Lilly, and Pfizer. Dr. Lillie has nothing to disclose. Dr. Dueck has nothing to disclose. Dr. Straus has nothing to disclose. Dr. Perrier has nothing to disclose. Dr. Aviv has nothing to disclose. Dr. Thorpe has nothing to disclose. Dr. Feasby has nothing to disclose. Dr. Spears has nothing to disclose.Wednesday, April 25 2012, 14:00 pm-19:00 pm ER -