@article {MezP04.209作者={杰西Mez和斯蒂芬妮张家港基地和亚当Brickman和爱德华·休伊和詹妮弗男子气概和理查德马斯},title ={表征Dysexecutive和遗忘{\ textquoteright}年代老年痴呆症表型在全国老年{\ textquoteright}协调中心(NACC)数据库(P04.209)},体积={78}={1}补充数量,页面= {P04.209——P04.209} ={2012},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:比较人口和血管Dysexecutive表型的特点和APOE基因型{\ textquoteright}年代老年痴呆症(广告)的遗忘表型在疾病早期广告课程。首页背景虽然广告{\ textquotedblleft}经典{\ textquotedblright}礼物与主要情景记忆赤字,表示相当异类。dysexecutive综合症患者这样的一个变种,在{\ textquotedblleft}赤字计划,判断,推理,解决问题,组织,关注,抽象和思维灵活性。{\ textquotedblright}人口、血管危险因素和载脂蛋白E4地位dysexecutive综合症的广告已经不够学习或研究了相互矛盾的结果。设计/方法:2224名参与者从NACC数据库进行诊断的单域遗忘轻度认知障碍(aMCI) (n = 637),多个域aMCI (n = 551)或轻度AD (CDR < = 1) (n = 1036)包括在这项研究中。aMCI (n = 61)的一个子集和温和的广告(n = 79)的参与者进行了尸检。dysexecutive表型(n = 587)被定义为在执行性能\ < 1 SD比内存性能和一个遗忘的表现型(n = 549)的定义相反。在病理子集,AD病理诊断的可能性相比在两个表型。人口统计、APOEε4地位和血管危险因素比较的两个表型。结果:解剖子集,拥有一个AD病理诊断的可能性没有dysexecutive和遗忘之间的表型差异。加性模型下,参与者与dysexecutive表型拥有APOEε4比遗忘表型的等位基因的频率更低。分层aMCI和温和的广告后,发现还重要。 After stratifying by ethnic group, whites (but not African Americans) with the dysexecutive phenotype possessed the APOEε4 allele less frequently than those with the amnestic phenotype. The two phenotypes did not differ in number of vascular risk factors.Conclusions: The dysexecutive phenotype of AD has distinct characteristics suggesting a unique underlying pathophysiology.Supported by: NIH grants: 5T32NS007153-27 and U01AG016976.Disclosure: Dr. Mez has nothing to disclose. Dr. Cosentino has nothing to disclose. Dr. Brickman has nothing to disclose. Dr. Huey has nothing to disclose. Dr. Manly has nothing to disclose. Dr. Mayeux has nothing to disclose.Wednesday, April 25 2012, 07:30 am-12:00 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/78/1_Supplement/P04.209}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }