PT -期刊文章盟詹姆斯·莫蒂默AU -艾米·伯伦斯坦盟Lorene Nelson TI -焊接协会与帕金森病和锰暴露:系统回顾和荟萃分析(P07.127) DP - 2012年4月26日TA -神经病学PG - P07.127 P07.127 VI - 78 IP - 1补充4099 - //www.ez-admanager.com/content/78/1_Supplement/P07.127.short 4100 - http://n.neuro首页logy.org/content/78/1_Supplement/P07.127.full所以Neurology2012 4月26日;78 AB -目的:检查焊接协会和锰暴露与帕金森病(PD)利用群体的出版数据的荟萃分析,病例对照研究和死亡率。背景案例报告表明,暴露在高水平的锰与锰中毒的发展有关。有人建议,焊工在PD的风险更高,因为它们可能接触锰通过吸入的烟。然而,协会的锰暴露与PD仍然是有争议的。设计/方法:焊接或锰暴露和PD相关流行病学研究发现使用PUBMED搜索从1974年到2011年,发表评论,从文章引用列表,发表摘要。研究包括是否符合以下标准:(1)队列,病例对照研究或死亡率相对危险度(RR),比值比(或)或死亡率优势比(铁道部)和95%可信区间;(2)研究匹配或调整年龄和性别;(3)有效的设计与分析。当参与者的一个研究小组的参与者的一个更大的研究中,只有更大的研究结果包括确保独立的数据集。集中风险估计和95%使用随机效应模型,求得了CIs和异质性的研究效果评估利用Q统计量和我²指数。研究结果:14(3组,8病例对照和3死亡率)符合入选标准。 The overall pooled RR for the association between welding and PD for all study designs was 0.86 (95% CI: 0.80-0.92; p<0.0001) with absence of between-study heterogeneity (I²=0.0). Effect measures for cohort, case-control and mortality studies were similar (0.87, 0.82, 0.85). For the association between manganese exposure and PD, the pooled OR was 0.80 (95%CI: 0.59-1.08).Conclusions: The findings from this meta-analysis demonstrate an inverse association between welding and PD and are incompatible with the observation that welding or manganese exposure increases the risk of PD.Disclosure: Dr. Mortimer has received personal compensation for activities with Davies, McFarland, and Carroll. Dr. Borenstein has nothing to disclose. Dr. Nelson has received personal compensation for activities with Goldberg and Segalla.Thursday, April 26 2012, 14:00 pm-18:30 pm