TY - T1的非侵入性的有效性测试小纤维神经病(P03.205) JF -神经学乔-神经病学SP - P03.205 LP - P03.205六世- 78 - 1补充AU -首页哈米德·伊巴迪AU -布鲁斯·珀金斯盟-汉斯Katzberg盟-维拉成Bril Y1 - 2012/04/24 UR - //www.ez-admanager.com/content/78/1_Supplement/P03.205.abstract N2 -目的:本研究的目的是评估不同的方法的准确性进行评估的小纤维神经病(SFN)使用内部表皮神经纤维密度(IENFD)作为参考标准。背景IENFD SFN的当前评分标准但侵袭性限制,费用和可用性。燥热引起神经源性血管舒张的激光多普勒成像(LDI),冷(CDT)检测阈值和热感知(HP)的神经功能替代的精度相对于形态IENFD是未知的。设计/方法:我们进行了回顾性的图表总结75例疑似SFN的多伦多综合医院,从2008 - 2011年大学健康网络。一份详细的病史和临床检查、实验室研究、神经传导研究(nc), CDT,惠普,LDI IENFD中执行所有的病人。我们定量比较结果的临床评估,包括疼痛视觉模拟量表(血管),相对于IENFD LDI, CDT和惠普SFN的诊断。结果:平均IENFD为7.52 + / - 4.12与7.59的中位数和四分位范围4.64 - -10.91(25%到75%)。34.7% had abnormal IENFD and 65.3% had normal IENFD according to published criteria (normal defined as > 5.4 fibers/mm). Low-magnitude correlation was observed between IENFD and CDT (R2 =0.0812, p< 0.0149) and sural nerve amplitude (R2 =0.2273, p< 0.0001) but not with HP (R2 =0.007, p=0.4823), or LDI (R2 =0.0177, p=0.2612), or VAS ((R2 =0.00693, p=0.4962). CDT was associated with the best diagnostic performance of small fiber tests with sensitivity of 68% and specificity of 65%.Conclusions: None of the objective measures reflected IENFD with very good diagnostic validity, but of these small fiber non-invasive methods, CDT had the highest level of accuracy, while we could not demonstrate acceptable performance of LDI. Alternate non-invasive methods for the determination of small fiber function or morphology are urgently needed.Disclosure: Dr. Ebadi has nothing to disclose. Dr. Perkins has nothing to disclose. Dr. Katzberg has received personal compensation for activities with Genzyme as a speaker and participant on an advisory board. Dr. Katzberg has received research support from Griffolds Biotherapeutics. Dr. Bril has received personal compensation for activities with Talecris Biotherapeutics as a consultant. Dr. Bril has received research support from Talecris Biotherapeutics.Tuesday, April 24 2012, 14:00 pm-18:30 pm ER -