Jiwon哦% % 0期刊文章%凯萨琳Zackowski Scott Newsome %一分钟陈% %杰瑞·王子赛斯史密斯% % Reich丹尼尔彼得•卡拉布雷西% % T扩散张量和磁化传递成像的运动功能障碍相关的脊髓多发性硬化(S21.002) % D J神经病学2012% % P S21.002-S21.002 % V 78% N 1补充% X目的:我们假设脊髓扩散张量成像(DTI)(地铁)关联指数和磁化传递率与运动功能障碍和全球残疾多发性硬化症(MS)。首页背景脊髓病理临床残疾是一个主要贡献者女士常规MRI脊髓的临床与影像学表现赤字相关的能力有限。脊髓横截面积(CSA)已被证明与适度与临床功能障碍,但脊髓萎缩是一种晚期疾病效果。使用MRI定量指标对早期和晚期脊髓显微结构的变化,我们评估的存在更好的MRI-clinical相关性MS.Design /方法:64患者复发和进步女士接受颈椎脊髓MRI在3 t和下肢运动强度的定量测试使用测力法。自动分割协议被用来描述感兴趣的区域包括绳CSA之间轴向片同样的。分数各向异性(FA)、平均扩散系数(MD)、垂直扩散系数(λ⊥),平行扩散系数(λ| |),和地铁被计算。皮尔森相关系数是用来评估MRI指数和测力法之间的关系。多元线性回归分析确定MRI与测力法和eds独立指标。结果:Multiparametric MRI颈线相关的指数适度与测力法(FA: r = 0.33, p = 0.01;MD: r = -0.42, p < 0.01;λ⊥:r = -0.45, p < 0.01;λ| |:r = -0.24, p = 0.07; MTR: r=0.25,p=0.05). In the progressive MS subtypes, DTI indices correlated strongly with dynamometry(FA: r=0.59,p=0.01; MD:r=-0.64,p<0.01; λ⊥:r=-0.71,p<0.01). In multivariate regression models adjusting for age, sex, brain parenchymal fraction, and cord CSA, MRI indices independently explained variability in dynamometry(p-values:FA=0.11, MD<0.01,λ⊥<0.01,λ||=0.02,MTR=0.06) and EDSS(p-values:FA<0.01,MD<0.01,λ⊥<0.01,λ||=0.22,MTR=0.04).Conclusions: Multiparametric MRI indices show moderate to strong correlations with motor dysfunction and EDSS and provide important information on the microstructural basis of limb dysfunction in MS. The ability to establish stronger structure-function correlations will enable enhanced investigation into the neuroanatomical pathways that form the substrate for MS-related disability, which will allow improved assessment of targeted therapies.Supported by: MS Society of Canada, National MS Society, EMD-Serono.Disclosure: Dr. Oh has nothing to disclose. Dr. Zackowski has nothing to disclose. Dr. Chen has nothing to disclose. Dr. Newsome has nothing to disclose. Dr. Smith has nothing to disclose. Dr. Prince has received personal compensation for activities with Diagnosoft, Inc. as a consultant.Dr. Prince has received (royalty or license fee or contractual rights) payments from Diagnosoft, Inc.Dr. Prince holds stock and/or stock options in Diagnosoft, Inc. Dr. Calabresi has received personal compensation for activities with Teva, Biogen Idec, Novartis, Genzyme, Johnson & Johnson, and Vertex. Dr. Calabresi has received research support from Biogen Idec, Teva, EMD Serono, Vertex, Genentech, Abbott, and Bayer. Dr. Reich has nothing to disclose.Wednesday, April 25 2012, 14:00 pm-15:45 pm %U

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