首页TY - JOUR T1 - Diffusion Tensor and Magnetization Transfer Imaging Correlates of Motor Dysfunction in the Spinal Cord in Multiple Sclerosis (S21.002) JF - Neurology JO - Neurology SP - S21.002 LP - S21.002 VL - 78 IS - 1 Supplement AU - Jiwon Oh AU - Kathleen Zackowski AU - Min Chen AU - Scott Newsome AU - Seth Smith AU - Jerry Prince AU - Peter Calabresi AU - Daniel Reich Y1 - 2012/04/25 UR - //www.ez-admanager.com/content/78/1_Supplement/S21.002.abstract N2 - Objective: We hypothesized that spinal cord diffusion tensor imaging(DTI) indices and magnetization transfer ratio(MTR) would correlate strongly with motor dysfunction and global disability in multiple sclerosis(MS).Background Spinal cord pathology is a major contributor to clinical disability in MS.传统MRI脊髓容量有限,无法将临床缺陷与成像发现相联脊髓交叉面积证明与临床机能失常有中度关联,但线性萎缩是一种晚期疾病效果使用量性磁共振指数敏感于脊髓早期和晚微结构变化,我们评估MS.Detimation/Methods中是否有更好的MRI-Clinic关联性:64名重迭和累进MS3T测试宫颈脊髓MRI并用Dya自动分割协议用于划分C3-C4间轴切带覆盖带CSAfractional反射性(FA)、平均diffiversity(MD)、双视diffiversity(NQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ皮尔逊相关系数用于评估MRI指数和反学关系多变量线性回归分析确定MRI指数是否独立关联domasysmss和EDSS.Results:多参数MRI指数MD:R=-0.42p <0.01R=-0.45p <0.01R=-0.24p=0.07半导体:r=0.25p=0.05递进MS子类型中,DTI指数与反学关系密切(FA:R=0.59p=0.01MD:r=-0.64,p<0.01!λ⊥:r=-0.71,p<0.01).多变量回归模型调整年龄、性别、脑粒子和链式CSA,MRI指数独立解释domasy(p值:0.11,MD < 0.01,QQ0.01,QQN2,MTR=0.06)和EDSS(p值:FA<0.01,MD<0.01,QQNO01,NGE2,MTR=0.04)变异性,多参数MRI指数显示运动机能失常和EDSS中度至强关联,并提供关于MS机机机机机机机机机机机失乱微基础的重要信息建立更强结构函数关联性的能力将增强神经剖析路径调查,这些路径组成MS相关残疾基底,从而改进目标疗法评估。没什么可透露的博士扎科夫斯基没有什么可透露博士陈公义博士Newsome没什么可透露博士Smith没什么可透露博士Prince因Diagnooft公司的活动得到个人补偿咨询师DrPrince从 Diagnosoft公司收到付款(代理费或许可费或合同权)Prince持有诊断软件公司股票和/或股票选择博士Calabresi因与Teva、BiogenIdec、Novartis、Genzyme、Johnson & Johnson和Vertex等公司活动而获得个人补偿博士Calabresi从BiogenIdec、Teva、EMDS Serono、Vertex、Genentech、Abbott和Bayer获得研究支持博士leich没有什么可透露的.Wednessday,2012年4月25日14点15分45分ER

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