% 0期刊文章%一个Raffaella Romano卡拉Tortorella % % % Maddalena Ruggieri维塔Direnzo %一个Mariangela Mastrapasqua %一个保罗Taurisano Pietro Iaffaldano % %一个达芬奇法齐奥% Elena Luciannatelli %一个朱塞佩•布拉西Teresa Popolizio % %亚历桑德罗·Bertolino %玛丽亚Trojano % T认知障碍与脑脊液神经丝水平临床孤立综合征暗示了多发性硬化症。功能性核磁共振研究(P04.104) % D J神经病学2012% % P P04.10首页4-P04.104 % V 78% N 1补充% X目的:探讨脑脊液(CSF)的相互作用神经丝(NF)水平和功能磁共振成像在认知活动的模式临床孤立综合征患者提示多发性硬化症(CIS)。背景fMRI显示早期神经激活在独联体的适应性变化。Neuro-axonal损伤的主要病理因素被认为是认知障碍和CSF NF证明是一个合适的工具来评估体内Neuro-axonal障碍。设计/方法:功能磁共振成像进行24未经处理的CIS患者和37个年龄和性别匹配的健康对照组(高碳钢)在n - back和可变注意力控制(休假)的任务。CSF NF轻链(NFL)是由一个标准评估ELISA。NFL水平高于中值被认为是高。SPM5随机模型用于功能性磁振造影资料统计分析(p < .005)。结果:患者高和低橄榄球水平socio-demographic没有差别,临床和MRI变量。行为数据展示一个更好的准确性在高碳钢休假和n - back试验相比,CIS患者和WM和注意力表演的一个重要交互认知负荷。“高NFL”在DLPFC BOLD-fMRI反应更大,在n - back和真空吸尘器的任务相比,“低橄榄球”组和高碳钢。真空吸尘器功能磁共振成像分析显示一个NFL水平和认知负荷之间的相互作用在双边额下回,右壳核和左DLPFC:高碳钢和“低橄榄球”组皮质活动的增加线性增加注意力的需求,而“高NFL”集团增加活动在中级水平和减少活动高度的注意力需求。结论:分析证实了功能磁共振成像的大脑活动的障碍在独联体WM和注意力的任务和注意的过程表明负载相关的障碍。 Brain recruitment abnormalities in CIS are related to CSF NFL levels suggesting a role of NFL as a surrogate outcome in neuroprotective trials.Disclosure: Dr. Tortorella has received personal compensation for activities with Biogen Idec, Sanofi-Aventis Pharmaceuticals and Novartis as a speaker. Dr. Romano has nothing to disclose. Dr. Ruggieri has nothing to disclose. Dr. Direnzo has nothing to disclose. Dr. Mastrapasqua has nothing to disclose. Dr. Iaffaldano has nothing to disclose. Dr. Taurisano has nothing to disclose. Dr. Fazio has nothing to disclose. Dr. Luciannatelli has nothing to disclose. Dr. Popolizio has nothing to disclose. Dr. Blasi has nothing to disclose. Dr. Bertolino has nothing to disclose. Dr. Trojano has received personal compensation for activities with Bayer Pharmaceuticals Corporation, Biogen Idec and Sanofi-Aventis Pharmaceuticals, Inc. as a consultant and/or speaker. Dr. Trojano has received research support from Merck & Co., Inc.Wednesday, April 25 2012, 07:30 am-12:00 pm %U