首页TY - JOUR T1 - Direct Correlations of [H-3]Flutemetamol Binding with [H-3]PiB Binding and Amyloid-beta Concentration and Plaque Load in [C-11]PiB Imaged Brains (S34.002) JF - Neurology JO - Neurology SP - S34.002 LP - S34.002 VL - 78 IS - 1 Supplement AU - Milos Ikonomovic AU - Julie Price AU - Eric Abrahamson AU - Chester Mathis AU - William Paljug AU - Manik Debnath AU - Lan Shao AU - Carl Becker AU - Ronald Hamilton AU - William Klunk Y1 - 2012/04/25 UR - //www.ez-admanager.com/content/78/1_Supplement/S34.002.abstract N2 - Objective: The goal of the current study was to determine if flutemetamol binding reflects the extent of Alzheimer's disease (AD) pathology and Pittsburgh Compound-B (PiB) binding in postmortem brain tissues, and if it correlates with carbon-11 labeled PiB ([C-11]PiB) retention recorded antemortem in the same subjects.Background Flutemetamol is a new in vivo amyloid imaging agent labeled with fluorine-18 which has a longer half-life than [C-11]PiB.Fritemetamol和PiB对AD大脑是否有相似绑定作用和类似辨识Abta封存能力未知高荧光衍生Fritemetamol(6-CN-Flutemetamol)和PiB(6-CN-PiB)和Abeta免疫学解析冷冻组织同质处理[H33Flutemetamol和[H3PiB绑定解析,Abeta1-42由ELISA测定死后数据与Vivo[C-11]PiBPET保留数据记录同题的死前记录比较 Results:6-CN-Flutematamol标签与6-CN-PiB和Abeta牌类比,而它没有检测神经纤维结核H3Flutematamol绑定直接关联到所有脑区[H3PiB绑定(r=0.98)和Abeta1-42peptide集中度(r=0.92)C-11PiBDVR值与死后6-CNFlutematamol牌负载(r=0.48)和[H-3Flutematamol绑定(r=0.58)在所有脑区直接相关PiBDVR值和6-CN-PiB模块负载(r=0.51或[H3++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++阿贝塔病理学范围通过fritemetamol检测到,类似于解剖组织使用PiB和Vivo使用PiBF18Flutemetamol与C-11PiB相似,它检测脑Abta病理学生存对象。支持者有:国家卫生院AG025204、AG15133、AG14449和GEHEIkonomovic以GEHealthCourse顾问身份获得个人补偿博士Ikonomovic接受GE保健研究支持博士Price没什么可透露博士亚伯拉罕森没有什么可透露博士Mathis没什么可透露博士Paljug没什么可透露博士Debnath没有什么可透露博士小萧没什么可透露博士贝克尔没什么可透露博士汉密顿没有什么披露博士Klunk公司因与Elan公司、Pfizer公司、AztraZeneca药房公司、Roche诊断公司、Eli Lily公司和Janssen咨询公司的活动而获得个人补偿博士Klunk从GEHealthCourse收到付款博士Klunk持有Neuroptix公司股票和/或股票选择权klunk参与调查员工作.2012年4月25日星期三14:00-17:30ER-