% % 0期刊文章% Marc De支持者大卫赫伯特西蒙Borghs % %约翰•肯尼思•缘故%乔伊斯·克莱默% T Lacosamide添加到伴随aed分组的作用机制:影响Patient-Reported健康相关的生活质量集中II / III期试验(P06.114) % D J神经病学2012% % P P06.114-P06.114 % V 78% N 1补充% X目的:评价癫痫患者的生活质量量表(QOLIE-31)分数lacosamide-treated患者分组的钠channel-blocking(渣打银行)属性的同时抗癫痫药物(aed)。首页背景前池的探索性分析数据从三个II / III期试验(SP667、SP754 SP755)评估疗效和安全性lacosamide, AED批准成人患者的辅助治疗部分性癫痫,分组的渣打银行属性相伴AED。设计/方法:意味着QOLIE-31得分变化从基线到年底维护进行评估(LOCF)。患者分成两组:渣打银行+(≥1传统渣打银行同时AED在基线(卡马西平、拉莫三嗪、奥卡西平和/或苯妥英衍生品])或者渣打银行。结果:1046例QOLIE-31数据,868(83%)遇到了渣打银行+标准。在渣打银行+集团lacosamide 200或400 mg / d组(n = 174, n = 317)显示最大改进发作(+ 6.42,+ 6.31)担心,但药物效果恶化(400毫克/天;-4.26)。患者随机分配到lacosamide 600 mg / d (n = 121)显示恶化(1 - -3.57)在所有分量表除了没收担心(+ 4.72)。在渣打银行集团lacosamide 200 mg / d (n = 40)与临床有意义的改善社会功能(+ 4.17),和改善癫痫担心(+ 5.37)。改进所有分量表除了药物治疗效果(-4.21)观察患者服用lacosamide 400 mg / d (n = 67)。Lacosamide 600 mg / d (n = 19)显示显著的临床意义的改进发作担心(+ 25.04)和社会功能(+ 9.78),改进药物效应(+ 4.39),总分3.97(+)和能源/疲劳(+ 3.68),和其他分量表上没有改进。结论:在这篇文章的探索性分析,lacosamide QOLIE-31分量表上的影响是依赖于剂量和渣打银行相伴AED方案的属性。添加lacosamide高达400毫克/天的治疗患者的任意组合AED导致总体稳定健康相关生命质量。最大的子组之间的差异被发现在患者lacosamide 600 mg / d。支持:UCB制药。Disclosure: Mr. De Backer has received personal compensation for activities with UCB Pharma S.A. as an employee.Mr. De Backer has received compensation for serving on the board for UCB Pharma. Dr. Borghs has received personal compensation for activities with UCB Pharma SA as an employee. Dr. Herbert has received personal compensation for activities with UCB Pharmaceuticals as an employee. Dr. Sake has received personal compensation for activities with UCB Pharma as an employee. Dr. Cramer has received personal compensation for activities with Bial, Eisai Inc., Sepracor, and UCB Pharma.Thursday, April 26 2012, 07:30 am-12:00 pm %U