PT -期刊文章盟布莱恩·科普兰AU -盖Ellmore AU -米歇尔Beurlot盟-清华梁AU -杰西卡Suescun盟艾琳Furr-Stimming AU -理查德Castriotta盟米娅Schiess TI -感兴趣的区域的测量结构卷帕金森氏症患者,非典型帕金森症,和REM睡眠行为障碍:基线测量从一个前瞻性纵向研究(P06.076) DP - 2012年4月26日TA -神经病学PG - P06.076 P06.076 VI - 78 IP - 1补充4099 - //www.ez-admanager.com/content/78/1_Supplement/P06.076.short 4100 - //www.ez-admanager.com/content/78/1_Supplement/P06.076.full所以Neurology2012 4月26日;首页78 AB -目的:测量基线磁共振成像(MRI)的选择解剖结构在特发性帕金森病(PD)患者,非典型震颤麻痹(PS), REM睡眠行为障碍(RBD),与健康对照组前瞻性纵向研究。背景RBD被认为是亚临床的神经退行性疾病,在PD和PS通过几十年的发展。设计/方法:地区感兴趣的基线的嗅球(OB)、壳核、尾状核,杏仁核,海马,和内嗅灰色使用3 t MRI测量PD (N = 12), PS (N = 10), RBD (N = 9)和控制(N = 10)组。OB卷测量手动而其他人被自动计算。卷被规范化为全脑体积和转化为大脑总额的百分比为每个单独的主题。社会团体内部的和组间差异分析意义使用均值±s.e.m。结果:社会团体内部的差异显著的OB RBD组(p = 0.050, = 0.125±0.027,对吧= 0.102±0.022),内果皮PD组(p = 0.043, = 2.240±0.085,对吧= 2.356±0.084),和杏仁核在PD, RBD,对照组(p = 0.010, = 0.642±0.023,对吧= 0.697±0.021;p = 0.003, = 0.629±0.030,对吧= 0.688±0.034;p = 0.020, = 0.632±0.023,左右分别= 0.696±0.029)。有显著的组间差异的规范化左尾状的PS和RBD (p = 0.0164, p = 1.839±0.1012, RBD = 1.538±0.03923)和与控制(p = 0.0318, p = 1.839±0.1012,控制= 1.579±0.04756),标准化的右尾状的PS和控制(p = 0.0196, p = 1.828±0.09645,控制= 1.536±0.06013),和标准化的尾状总量的PS和RBD (p = 0.0209, p = 3.667±0.1954, RBD = 3.099±0.08852)和与控制(p = 0.0205, p = 3.667±0.1954,控制= 3.116±0.09428)。结论:初步基线结构体积是面对社会团体内部的差异中发现PD的杏仁核,RBD,对照组和OB RBD患者。 Intergroup differences were found in the caudate volumes of the PS group versus RBD and controls. These measurements provide a baseline for evaluation over time and future correlation with behavioral and clinical measures.Disclosure: Dr. Copeland has nothing to disclose. Dr. Ellmore has nothing to disclose. Dr. Beurlot has nothing to disclose. Dr. Liang has nothing to disclose. Dr. Suescun has nothing to disclose. Dr. Furr-Stimming has nothing to disclose. Dr. Castriotta has nothing to disclose. Dr. Schiess has nothing to disclose.Thursday, April 26 2012, 07:30 am-12:00 pm

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