PT -期刊文章盟伊莎贝拉西蒙盟Domenico Mezzapesa盟- Eustachio D 'Errico盟语言Dicuonzo AU -斯特凡诺Zoccolella AU - Rosanna Tortelli盟罗莎Cortese AU -弗朗西斯科·费德里科•AU -吉安卡洛Logroscino AU -保罗Livrea TI -在额叶皮质萎缩与快速发展的肌萎缩性脊髓侧索硬化症(P03.161) DP - 2012年4月24日TA -神经病学PG - P03.161 P03.161 VI - 78 IP - 1补充4099 - //www.ez-admanager.com/content/78/1_Supplement/P03.161.short 4100 - //www.ez-admanager.com/content/78/1_Supplem首页ent/P03.161.full所以Neurology2012 4月24日;78 AB -目的:在这个工作我们大脑皮质厚度测量(CT)样本的肌萎缩性脊髓侧索硬化症(ALS)患者的疾病持续时间,为了探索而一些地区可能与快慢有关进展。背景ALS是一种神经退行性疾病的运动神经元异构的临床表型,残疾进展和预后。一些研究调查了脑CT与临床特征的相关性,病人和疾病进展特别是美国手语。设计/方法:23可能的或明确的ALS患者进行了研究(一半的患者疾病持续时间超过24个月)。缓慢或快速发展的定义根据索引,包括疾病的持续时间和严重程度。使用FreeSurfer CT测量从3 d-mri,一组自动化工具重建大脑皮质的表面。执行统计数据在整个大脑vertex-wise和在哪些地区水平。结果:ALS患者相比,控制显示皮质萎缩对尾额中回(生产厂),右额上回(SFG)和左梭状回(FG)。患者快速进展显示,双边MFG变薄,在右SFG和左FG相比控制。没有发现领域的皮质萎缩患者进展缓慢而控制。Conclusions: Our study demonstrated that in term of brain CT the hallmark of ALS is located in the frontal lobes, without a direct involvement of the primary motor areas. The cortical thinning regards mostly the bilateral MFG of patients with faster evolution, as if it characterizes different phenotypes in term of disease progression.Supported by: Research grant Progetto Ordinario Regione Puglia 2007-652596.Disclosure: Dr. Simone has received personal compensation for activities with Sanofi-Aventis and Biogen Idec. Dr. Mezzapesa has nothing to disclose. Dr. D'Errico has nothing to disclose. Dr. Dicuonzo has nothing to disclose. Dr. Zoccolella has nothing to disclose. Dr. Tortelli has nothing to disclose. Dr. Cortese has nothing to disclose. Dr. Federico has nothing to disclose. Dr. Logroscino has received personal compensation for activities with Novartis, Glaxo and Boerhinger. Dr. Livrea has received personal compensation for activities with Sanofi-Aventis, Pfizer, Novartis, and Lundbeck as a speaker.Tuesday, April 24 2012, 14:00 pm-18:30 pm