RT期刊文章SR电子T1在额叶皮质萎缩与快速发展的肌萎缩性脊髓侧索硬化症(P03.161)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P03.161 OP P03.161 VO 78是1补充A1伊莎贝拉西蒙A1 Domenico Mezzapesa A1 E首页ustachio D 'Errico A1语言Dicuonzo A1斯特凡诺Zoccolella A1罗赞娜Tortelli A1罗莎Cortese A1 Francesco费德里科•A1吉安卡洛Logroscino A1保罗Livrea年2012 UL //www.ez-admanager.com/content/78/1_Supplement/P03.161.abstract AB目的:在这个工作我们大脑皮质厚度测量(CT)样本的肌萎缩性脊髓侧索硬化症(ALS)患者的疾病持续时间,为了探索而一些地区可能与快慢有关进展。背景ALS是一种神经退行性疾病的运动神经元异构的临床表型,残疾进展和预后。一些研究调查了脑CT与临床特征的相关性,病人和疾病进展特别是美国手语。设计/方法:23可能的或明确的ALS患者进行了研究(一半的患者疾病持续时间超过24个月)。缓慢或快速发展的定义根据索引,包括疾病的持续时间和严重程度。使用FreeSurfer CT测量从3 d-mri,一组自动化工具重建大脑皮质的表面。执行统计数据在整个大脑vertex-wise和在哪些地区水平。结果:ALS患者相比,控制显示皮质萎缩对尾额中回(生产厂),右额上回(SFG)和左梭状回(FG)。患者快速进展显示,双边MFG变薄,在右SFG和左FG相比控制。没有发现领域的皮质萎缩患者进展缓慢而控制。结论:我们的研究表明,在脑CT ALS位于额叶的标志,没有直接参与的主要运动区。 The cortical thinning regards mostly the bilateral MFG of patients with faster evolution, as if it characterizes different phenotypes in term of disease progression.Supported by: Research grant Progetto Ordinario Regione Puglia 2007-652596.Disclosure: Dr. Simone has received personal compensation for activities with Sanofi-Aventis and Biogen Idec. Dr. Mezzapesa has nothing to disclose. Dr. D'Errico has nothing to disclose. Dr. Dicuonzo has nothing to disclose. Dr. Zoccolella has nothing to disclose. Dr. Tortelli has nothing to disclose. Dr. Cortese has nothing to disclose. Dr. Federico has nothing to disclose. Dr. Logroscino has received personal compensation for activities with Novartis, Glaxo and Boerhinger. Dr. Livrea has received personal compensation for activities with Sanofi-Aventis, Pfizer, Novartis, and Lundbeck as a speaker.Tuesday, April 24 2012, 14:00 pm-18:30 pm