PT -期刊文章盟理查德帕特尔普盟Jeffrey节省TI -再灌注治疗急性脑的进化和急性心肌缺血:一个系统的比较分析(P04.054) DP - 2012年4月25日TA -神经病学PG - P04.054 P04.054 VI - 78 IP - 1补充4099 - //www.ez-admanager.com/content/78/1_Supplement/P04.054.short 4100 - http://n首页.neurology.org/content/78/1_Supplement/P04.054.full所以Neurology2012 4月25日;78 AB -目的:执行系统的历史发展的比较,再灌注干预脑血管和心血管的发行量。背景早期再灌注是最有效的治疗急性脑和急性心肌缺血。然而,大脑床提供了更多的挑战:更大的血块,曲折的动脉,末梢器官出血。设计/方法:Medline检索识别执行所有相关的冠状动脉重建术对急性心肌梗死的大脑血管再生和多中心试验与再灌注导管造影评估急性缺血性中风。部分再灌注(PR - TIMI 2或3)和完整的再灌注(CR - TIMI 3),样本量,干预类型和报告进行了分析。结果:41试验的冠状动脉再灌注招收了11946名患者从1983 - 2007年和10试验脑再灌注招收了1071名病人从1992年到2008年。冠状动脉再灌注试验包括15静脉注射纤维蛋白溶解(IVF)仅从1983年至2004年,公关加权平均值71.0%,铬54.7%;17的体外受精和PTCA±S从1983 - 2007年,公关86.0%,铬79.1%;和9的PTCA±S从1995 - 2005年,公关88.3%,铬81.9%。脑再灌注试验包括1受精仅1992年,公关43.2%,铬22.3%; 4 of endovascular fibrinolysis or device alone from 1998-2005, with PR 50.5%, CR 18.2%; and 5 of endovascular ± IVF from 1999-2009, with PR 66.3%, CR 25.4%. Over time, in the coronary bed, PR increased by 1.1%/yr, CR by 2.6%/yr. Epoch changes: pre 1995, PR-70.8%, CR-49.3%; 1995-2004, PR-82.2%, CR-74.1%; 2005-2010, PR-83.7%, CR-76.6%. In the cerebral bed, PR increased by 1.3%/yr, CR 0.5%/yr. Epoch changes: pre 1995, PR-43.2%, CR-22.3%; 1995-2004, PR-54.3%, CR-17.5%; 2005-2010, PR-61.1%, CR-23.4%.Conclusions: Cerebral reperfusion therapies, compared with cardiac, developed more slowly and remain considerably less effective. Technical advances tailored to the cerebral circulation are required for physicians to become as capable at restoring blood flow to the ischemic human brain as the ischemic human heart.Supported by: NIH-NINDS.Disclosure: Dr. Patel has nothing to disclose. Dr. Saver has received personal compensation for activities with BrainsGate, CoAxia, ev3, Talecris, PhotoThera, and Sygnis. Dr. Saver has received research support from the NIH, ev3, and Concentric.Wednesday, April 25 2012, 07:30 am-12:00 pm