TY - T1的光谱分析心率变异性在SCA中3 (P05.191) JF -神经学乔-神经病学SP - P05.191 LP - P05.191六世- 78 - 1补首页充非盟-卡伦Takazaki盟Anelyssa D 'Abreu盟Iscia Lopes-Cendes AU - Anamarli Nucci AU - Marcondes语言,Jr Y1 - 2012/04/25 UR - //www.ez-admanager.com/content/78/1_Supplement/P05.191.abstract N2 -目的:调查患者的心率变异性SCA3使用RR休息间隔的光谱分析。背景3型脊髓小脑的共济失调(SCA3)是最常见的常染色体显性共济失调和显著的临床异质性的特征。疾病中的多个受损的神经细胞群,在中央自主神经系统和周围神经系统的参与在SCA3 / MJD最近承认,但很少有系统的研究。设计/方法:我们选择了27个SCA / MJD患者和19控制年龄和性别相匹配。共济失调的规模评估和评级(SARA)和帕金森病的量表结果自主症状(SCOPA-AUT)被用来量化共济失调和自主功能障碍的严重程度,分别。功率谱分析的连续的rr间隔(5分钟)获得频域执行措施,包括高(高频;0.15 - -0.4赫兹)和低频功率(低频;0.04 - -0.15赫兹)和低频到高频的比率(LF / HF)心率变异性。结果:有15 SCA3的女性群体。患者的平均年龄为47.1±12.1年,平均长度(CAG)扩张是68年。意味着莎拉和SCOPA-AUT分数13.2(范围2.5 - -26)和23岁(范围5-58),分别。患者SCA3提出减少高频和低频控制相比,(34.7±46.2 vs 54.7±41.5一份,一份p = 0.004和26.6±24.1 vs 39.6±21.1一份,一份p = 0.004,分别)。低频/高频比两组相似(p = 0.075)。 We found no correlation between frequency-domain measures and SARA scores (p=0.95).Conclusions: Patients with SCA3 have autonomic cardiovascular dysfunction and reduced parasympathetic activity seems to play a key role.Disclosure: Dr. Takazaki has nothing to disclose. Dr. D'Abreu has received research support from Roche. Dr. Lopes-Cendes has nothing to disclose. Dr. Nucci has nothing to disclose. Dr. Franca has nothing to disclose.Wednesday, April 25 2012, 14:00 pm-19:00 pm ER -