% 0期刊文章%弗朗西斯卡卡索% Benno Gesierich %玛雅亨利%一个吉尔Rabinovici阿曼达LaMarre % %一个斯蒂芬·威尔逊%布鲁斯·米勒%威廉·斯利%玛丽亚·路易萨Gorno-Tempini % T迟滞型/ Agrammatic变体的PPA加以积极的PET扫描和皮克病病理(P07.171) % D J神经病学2012% % P P07.171-P07.171 % V 78% N 1补充% X目的:强调的重要性,结合临床,病理解剖和分子成像数据在预测潜在的原发性进行性失语(PPA)。首页背景预测的具体病理的额颞叶痴呆(FTD)临床表现可以挑战甚至有经验的临床医生。分子成像生物标志物持有承诺改善检测AD患者临床FTD,但很少radio-pathological相关性研究的报告。设计/方法:在这里,我们介绍详细,从一位66岁的前瞻性纵向数据,右撇子的女人看到一个3年的历史进步的演讲和语言障碍。临床随访7年之前事后分析。结果:病人符合迟滞型变体PPA的标准(nfvPPA)有严重失用症的演讲。她很快成为哑巴,agrammatic写作。后来她患上了轻微的不对称的锥体束外的综合症,但通用汽车的症状没有禁用。分布形态测量学显示初始选择性萎缩的左后额下回(IFG)、岛叶和中央前回,后来扩展到包括左翼运动前区地带。发病后八年她接受PIB-PET成像,是正面的。去年她的病,她轻微的记忆障碍。尸检显示选择的疾病,严重的退化和Pick-type 3-repeat tauopathy涉及左IFG、孤立、和运动区域。阿尔茨海默疾病病理学包括频繁的神经炎的斑块和Braak V神经原纤维缠结病理阶段,无论是在典型解剖分布。至于基因分型结果,病人是APOE e3 / e3和τ单体型H1 / H1。她没有入库单突变蛋白。MAPT没有测序。结论:在这个病人,临床和解剖学特征典型nfvPPA,与严重的汽车演讲赤字导致她的临床医生预测潜在tauopathy。通用汽车的症状非常轻微,不保证corticobasal综合征诊断或进行性核上的麻痹症状。生物标志物的证据大脑淀粉样变不应被视为强有力的证据表明广告负责一个典型FTD综合症。Supported by: NINDS R01 NS050915, NIA P50 AG03006, NIA P01 AG019724;DHS04-35516;03-75271 DHS/ADP/ARCC;Larry L. Hillblom Foundation;John Douglas French Alzheimer's Foundation;Koret Family Foundation;McBean Family Foundation.Disclosure: Dr. Caso has nothing to disclose. Dr. Gesierich has nothing to disclose. Dr. Henry has nothing to disclose. Dr. LaMarre has nothing to disclose. Dr. Rabinovici has received compensation for activities with Novartis Diagnostics as an advisory board member.Dr. Rabinovici has received research support from Avid Radiopharmaceuticals. Dr. Wilson has nothing to disclose. Dr. Miller has received personal compensation for activities with Allon Therapeutics, Inc. and TauRx Therapeutics, Ltd. Dr. Miller has received research support from Novartis. Dr. Seeley has received personal compensation for activities with Korea Novartis. Dr. Gorno Tempini has nothing to disclose.Thursday, April 26 2012, 14:00 pm-18:30 pm %U