TY - T1的微观结构改变的大脑成功HIV +轻微的神经认知障碍患者:Multi-Contrast MRI研究在高场(S37.001) JF -神经学乔-神经病学SP - S37.001 LP - S37.001六世- 78 - 1补充AU -克里斯蒂娜Granziera AU -亚历山德罗Daducci盟Samanta Simioni盟Matthias首页 Cavassini AU - Alexis罗氏盟Djalel Meskaldji盟——媚兰米歇尔盟——亚历山德拉Calmy AU -伯纳德Hirschel盟贡纳·克鲁格盟Renaud Du Pasquier Y1 - 2012/04/25 UR - //www.ez-admanager.com/content/78/1_Supplement/S37.001.abstract N2 -目的:探讨MRI标记微妙的艾滋病毒对大脑的影响。背景轻微的神经认知障碍(MND)影响HIV阳性病人的一个子集下有效的高活性抗逆转录病毒疗法(HAART)。然而MND的生理病理学是不清楚,一些成功的原因以及病人患有MND而其他不是。在这里,我们使用一个基于multi-contrast核磁共振方法在高场测试的假设成功aviremic MND +患者存在大脑不同显微结构特征相比,MND——艾滋病患者和健康对照组(HC)。设计/方法:我们招收17 MND + 19 MND -检测不到病毒血症患者和14与HC。在3 t MRI收购包括:MP2RAGE T1弛豫时间以及磁化传递(MT) T2 *和敏感加权成像(瑞士)探针显微结构完整性和铁沉积。感兴趣的区域自动提取了灰质和白质(WM,通用汽车)、丘脑、基底神经节和海马。使用多元统计分析permutation-based霍特林测试和修正family-wise错误率。线性判别分析MND +和MND患者之间进行利用不确定型的MRI数据(T1,太比率,瑞士),旨在分析测试。结果:多变量分析表明MND +和国防部之间有着显著的不同,患者在WM和通用(p = 0.02),和尾状MND +和HC之间(p = 0.02)。单变量分析表明,MND +患者太比率低于MND HC,达到意义在WM和尾状(p = 0.01)。线性判别分析杰出MND +和MND患者分类质量的0.73%交叉验证。Conclusions: Our findings show the presence of micro-structural brain alterations in MND+ patients as compared to MND- and HC, suggesting loss of structural integrity. In addition, they suggest that multi-contrast MRI at high field may be a powerful approach to understand the physiopathology of MND and to discriminate between patients' sub-groups.Supported by: Centre d'Imagerie BioMédicale of the University of Lausanne, the Swiss Federal Institute of Technology Lausanne, the University of Genève, the Centre Hospitalier Universitaire Vaudois, the Hôpitaux Universitaires de Genève, the Leenaards, the Jeantet and the Stoicescu foundations and the Swiss National Science Foundation Grant PZ00P3_131914/1.Disclosure: Dr. Granziera has nothing to disclose. Dr. Daducci has nothing to disclose. Dr. Simioni has received personal compensation for activities with Gilead and Boehringer Ingelheim as a speaker. Dr. Cavassini has nothing to disclose. Dr. Roche has received personal compensation for activities with Siemens AG as an employee. Dr. Meskaldji has nothing to disclose. Dr. Michel has nothing to disclose. Dr. Calmy has nothing to disclose. Dr. Hirschel has nothing to disclose. Dr. Krueger has received personal compensation for activities with Siemens AG as an employee. Dr. Krueger has received research support from Siemens AG. Dr. Du Pasquier has received personal compensation for activities with Merck Serono, Biogen Idec, Abbott, and ViiV.Wednesday, April 25 2012, 16:00 pm-17:30 pm ER -