TY -的T1 -增加皮质兴奋性:酒精戒断症状的机制?(P07.145) JF -神首页经学乔-神经病学SP - P07.145 LP - P07.145六世- 78 - 1补充AU - Radwa Badawy AU -阿曼达·诺曼AU -西蒙Vogrin AU -理查德Macdonell盟——艾伦•赖b Eng AU -马克·库克盟乔恩•柯里Y1 - 2012/04/26 UR - //www.ez-admanager.com/content/78/1_Supplement/P07.145.abstract N2 -目的:我们使用经颅磁刺激(TMS)调查是否运动皮质兴奋性的改变与慢性酒精摄入的量。背景实验数据表明慢性酒精暴露诱发大脑neuroadaptative变化中的兴奋和抑制性神经元回路,但这从未得到证实。因为缺乏直到最近的测量兴奋性和抑制性的平衡在人类。设计/方法:43参与者划分根据他们经常食用酒精在前12个月高,中等和低风险组进行两次,(i)在规律的饮酒和(2)从酒精弃权后至少24小时。电动机阈值,短皮层抑制([SICI]配对脉冲经颅磁刺激在2 5 ms interstimulus间隔(ISIs)),皮层便利(伊希斯女士(ICF) 10、15)和长皮层抑制([LICI] 100 - 300 ms ISIs)测量两次。20控制的结果相比,没有接触到酒精的历史。Results: During regular alcohol consumption, there was reduced ICF (p< 0.05, effect sizes ranging from 0.2-0.4) in the high risk group and enhanced LICI (p< 0.05, effect sizes ranging from 0.2-0.4) in the high and moderate risk groups compared to controls. After 24 hours of alcohol abstinence ICF increased (p < 0.05, effect sizes ranging from 0.4-0.7) in the high and moderate risk groups and SICI and LICI decreased in all three groups (p < 0.05, effect sizes ranging from 0.2-1.1). Cortical hyper-excitability was also noted in the high and moderate risk groups compared to controls (p< 0.05, effect sizes ranging from 0.2-0.5).Conclusions: Chronic alcohol consumption is associated with alterations within the intracortical excitatory and inhibitory systems. These changes may be a mechanism underlying alcohol withdrawal symptoms.Disclosure: Dr. Badawy has nothing to disclose. Dr. Cook has received research support from UCB Pharma. Dr. Vogrin has nothing to disclose. Dr. Norman has nothing to disclose. Dr. Currie has nothing to disclose.Thursday, April 26 2012, 14:00 pm-18:30 pm ER -