% 0期刊文章%克里斯汀•年度%斯科特彭定康乔纳森戴克曼% %一个Gilaad卡普兰%撒母耳Wiebe %娜塔莉Jette % T之间的关系抑郁症和癫痫:系统回顾和荟萃分析(P01.042) % D J神经病学2012% % P P01.042-P01.042 % V 78% N 1补充% X目的:以人群为基础的研究进行系统回顾和荟萃分析评估抑郁症和癫痫症之间的关系。首页背景癫痫的患病率估计每1000 6,和负担的癫痫是伟大的。癫痫与许多精神病的风险增加困难,包括自杀,焦虑和抑郁。抑郁往往病因和不当管理与癫痫的人,并且可以干扰治疗效果和生活质量。虽然主要的文学存在,据我们所知系统回顾抑郁症和癫痫症之间的关系并没有被执行。设计/方法:MEDLINE和EMBASE,和PsycINFO搜索周围使用术语抑郁,癫痫,以人群为基础的估计。两个独立的评论者筛选摘要和全文,从合格的抽象数据研究,解决分歧的共识。纳入研究的特征有:1)足够的数据来计算一个比值比(或)抑郁症比较有和没有癫痫;2)以人群为基础的抽样;3)队列或横断面研究设计;和4)完整的原始研究。排除研究:1)英语; or 2) did not describe epilepsy and depression determination. Heterogeneity was assessed using Cochran's Q statistic and quantified using I². The pooled OR was estimated using a random-effects model. Publication bias was assessed using the trim and fill method.Results: Of 6883 abstracts identified, 147 underwent full-text review and 11 studies, reporting on 7 unique samples, were included for data abstraction. None used a structured interview for depression diagnosis. There were 11716 participants with epilepsy and 1397354 participants without epilepsy. Significant heterogeneity (p<0.0001) was observed with an I2 of 96.96%. Trim and fill identified zero missing studies. There was a significant association between depression and epilepsy (pooled OR=2.43[1.77-3.35], p<0.0001).Conclusions: Epilepsy is associated with significantly increased odds of depression. Physicians managing patients with epilepsy should monitor for the presence of depression and intervene appropriately.Disclosure: Dr. Fiest has nothing to disclose. Dr. Dykeman has nothing to disclose. Dr. Patten has received personal compensation for activities with Cipher Pharmaceuticals and Servier.Dr. Patten has received research support from Servier. Dr. Kaplan has nothing to disclose. Dr. Wiebe has nothing to disclose. Dr. Jette has received research support from various sources.Monday, April 23 2012, 14:00 pm-18:30 pm %U