PT -期刊文章盟卡罗琳·坦纳盟凯萨琳Albers AU -塞缪尔高盛盟罗宾Fross Jeffrey Klingman AU -紫水晶Leimpeter盟盟——斯蒂芬·范Eeden TI -脂溢性皮炎和未来帕金森病(PD)的风险(S42.001) DP - 2012年4月26日TA -神经病学PG - S42.001 S42.001 VI - 78 IP - 1补充4099 - //www.ez-admanager.com/content/78/1_Supplement/S42.001.short 4100 - http://n.neurolo首页gy.org/content/78/1_Supplement/S42.001.full所以Neurology2012 4月26日;78 AB -目的:评估之间的关系,医学诊断脂溢性皮炎和患帕金森病的风险。背景自主神经系统(ANS)异常是常见的在PD和爆发可能会先于汽车特性。脂溢性皮炎提出了在PD ANS功能障碍的表现。设计/方法:在Kaiser Permanente加州北部,一个大型的、集成的卫生系统,我们确定了neurologist-diagnosed PD情况下匹配和控制了年龄,性别和持续时间的会员(1例:5控制)2006 - 2010。我们比较的频率医学诊断脂溢性皮炎索引日期之前(定义为病例诊断日期或一个等价的时间点在控制)。PD与脂溢性皮炎的风险估计在逻辑回归模型调整年龄、性别、吸烟。结果:平均年龄是74.1岁的2651例PD和73.2年13255匹配控制;58.2%的病例和对照组男性。索引日期前被诊断为脂溢性皮炎115例(4%)和333年(2.5%)控制。脂溢性皮炎与帕金森病的风险增加(或= 1.69,95% CI 1.36, 2.1;p < 0.001). PD risk was also increased when seborrheic dermatitis was diagnosed 5 or more years before the reference date (2.1% cases, 1.4% controls, OR= 1.42, 95% CI: 1.05, 1.93, p =0.024).Conclusions: Seborrheic dermatitis is associated with an increased risk of PD. This may represent a premotor feature, referable to the ANS. Seborrheic dermatitis, like other ANS abnormalities and hyposmia, may be useful in the early identification of persons with PD.Supported by: Kaiser Permanente Northern California; James & Sharron Clark.Disclosure: Dr. Tanner has received personal compensation for activities with Impax Pharmaceuticals, Allergan, Inc. & Genentech, Inc. as a consultant. Dr. Tanner has received research support from Michael J. Fox Foundation, Department of Defense, Parkinson's Disease Foundation, Parkinson's Institute, Unity Walk and Brin Foundation. Dr. Albers has nothing to disclose. Dr. Goldman has nothing to disclose. Dr. Fross has nothing to disclose. Dr. Leimpeter has nothing to disclose. Dr. Klingman has nothing to disclose. Dr. Van Den Eeden has received research support from GlaxoSmithKline, Inc.Thursday, April 26 2012, 13:00 pm-14:45 pm