TY - T1的认知和脑萎缩几十年后妊娠高血压疾病(P1.089) JF -神经学乔-神经学六世- 86 - 16补充SP - P1.089盟米歇尔Mielke AU -娜塔莎Milic盟特蕾西Weissge首页rber AU -温迪白色盟Kejal Kantarci AU -托马斯·莫斯利盟b格温温德姆AU -布列塔尼·辛普森AU -斯蒂芬·特纳盟-维斯纳Garovic Y1 - 2016/04/05 UR - //www.ez-admanager.com/content/86/16_Supplement/P1.089.abstract N2 -目的:检查妊娠高血压疾病和认知能力之间的关联和大脑核磁共振发现几十年后在一个多民族的女性样本。背景:以往的研究表明,妊娠高血压疾病与主观认知有关投诉或脑白质病变五到十年后妊娠高血压。长期高血压妊娠对大脑结构和认知功能的影响仍然未知。方法:本研究包括1167名妇女(平均年龄= 61年;标准差= 9)参与项目家庭血压动脉病的遗传流行病学网络(热那亚)研究。作为Microangiopathic脑损伤研究的辅助遗传学,神经认知电池管理。核磁共振测量了大脑,心室,白质病变卷972年女性。妊娠高血压疾病是通过自我报告的历史使用问卷调查进行验证。线性模型符合广义估计方程被用来评估妊娠高血压疾病之间的关系和认知调整年龄、种族、教育、身体质量指数、吸烟、高血压和高血压家族史。回归模型对大脑核磁共振结果也为颅内总额进行调整。 Results: Women with a history of hypertensive pregnancy disorders performed worse on all measures of processing speed: Digit Symbol Substitution Test (mean score 41.2 vs 43.4, p=0.005), Trail Making Test Part A (mean seconds 45.1 vs 42.2, p=0.035), and the Stroop (mean score 173.9 vs 181.0, p=0.002) and had smaller brain volumes compared to women with a history of normotensive pregnancies (286 vs 297, p=0.023). Conclusions: Hypertensive pregnancy disorders are associated with worse performance on tests of processing speed and smaller brain volumes decades later. Population-based studies are needed to provide critical insight as to the contribution of hypertensive pregnancies for risk of cognitive decline and dementia.Disclosure: Dr. Mielke has received personal compensation for activities with Lysosomal Therapeutics, Incorporated. Dr. Milic has nothing to disclose. Dr. Weissgerber has nothing to disclose. Dr. White has nothing to disclose. Dr. Kantarci has received personal compensation for activities with Takeda and Novartis. Dr. Mosley has nothing to disclose. Dr. Windham has nothing to disclose. Dr. Simpson has nothing to disclose. Dr. Turner has nothing to disclose. Dr. Garovic has nothing to disclose.Saturday, April 16 2016, 8:30 am-7:00 pm ER -