TY - T1的认知和功能错觉和幻觉之间的差异在阿尔茨海默氏症(P2.234) JF -神经学乔-神经学六世- 86 - 16补充SP - P2.234盟温妮千盟科琳费舍尔盟——汤姆·施魏策尔盟——大卫·穆尼奥斯Y1 - 2016/04/05 UR -首页 //www.ez-admanager.com/content/86/16_Supplement/P2.234.abstract N2 -目的:描述阿尔茨海默病(AD)的临床资料的精神病症状的患者,划定为那些妄想,幻觉,或两者兼而有之。背景:据估计,41 (percnt)的广告发展精神病患者的疾病,1/3出现错觉与幻觉和1/6。精神病在广告与增加相关认知和功能下降,疾病进展更快。从NACC数据库设计/方法:728例与病理证实广告诊断进行了分析。NPI-Q是用来识别对象与精神病和精神错乱的类型。精神病学科(广告+ P)和它的每个子组(错觉:广告+ D;幻觉:广告+ H;妄想和幻觉:广告+ DH)比较never-psychotic科目(AD-P)使用单变量的测试中,α= 0.05。结果:AD-P之间没有明显差异(n = 457)和广告+ P (n = 271)受试者死亡年龄,多年的教育、种族、性别、或功能(FAQ)和认知状况(MMSE, CDR)死前的最后一次访问。广告+ P有大大延长疾病持续时间计算从临床发病死亡年龄的时代。 Breakdown by psychotic symptoms showed that subjects with hallucinations(AD+H(n=52); AD+DH(n=79)) had increased cognitive and functional impairment while delusional subjects(AD+D,n=140) were less cognitively impaired than AD-P. The increased duration of disease was restricted to delusional subjects(AD+D and AD+DH). Conclusion:The contrast between AD patients who experienced delusions versus hallucinations has not been previously reported. Subjects with hallucinations had lower cognitive and functional status compared to non-psychotic subjects, while subjects with delusions had better cognitive status. A possible explanation is that expression of delusions requires some level of cognitive ability, and that delusions diminish with cognition. Data also show that psychotic subjects in general, and those with delusions in particular, had a slower disease progression, contrary to some literature. The distressing nature of psychotic symptoms may prompt these patients to seek medical attention earlier, creating artificially longer disease duration.Disclosure: Dr. Qian has nothing to disclose. Dr. Fischer has nothing to disclose. Dr. Schweizer has nothing to disclose. Dr. Munoz has nothing to disclose.Sunday, April 17 2016, 8:30 am-5:30 pm ER -