PT -期刊文章盟罗莎Cortese AU -丽丝Magnollay盟Floriana De旧金山AU -阿曼Eshaghi盟Francesco Grussu AU -弗兰普拉多盟Sebastien Ourselin盟腻过Yiannakas盟David Miller -伊莎贝拉劳拉·西蒙盟盟——克劳迪娅甘迪尼Wheeler-Kingshott盟——奥尔加Ciccarelli TI -没有脊髓的差异之间的白色和灰色物质扩散异常Neuromyelitis视谱系障碍和多发性硬化症(P4.151) DP - 2016年4月05 TA -神经病学PG - P4.151 VI - 86 IP - 16补充4099 - //www.ez-admanager.com/content/86/16_Supplement/P4.151.short 4100 - //www.ez-admanager.com/content/86/16_Supplement/P4.151.full所以Neurology2016 4月05;首页86 AB -目的:探索脊髓灰质(GM)的微观结构变化和白质(WM)患者的视神经节neuromyelitis谱系障碍(NMOSD)和比较他们患有多发性硬化症(MS)。背景:NMOSD女士和可能影响脊髓不同。扩散张量成像(DTI)可以反映体内的病理参与脊髓。方法:我们招募患者18 NMOSD(所有AQP4-antibody积极的两个除外),18与复发缓和多发性硬化症和22名健康对照组(高碳钢)。平均年龄是(NMOSD = 52年[±11],女士= 42[±10],高碳钢= 34 [±10])。意思是病程(NMOSD = 8.9年(±6.5)= 8.8(±7.1))女士。所有受试者3 t MRI测量线横截面积(CCA)和DTI指标(足总:各向异性扩散;广告/理查德·道金斯:数量的扩散/在神经纤维;MD:平均扩散)通用和WM(后和lateral-columns)。 Physical disability was assessed using the expanded-disability-status scale, 9-hole-peg test (HPT), timed-25-foot-walk test, handgrip-strength and vibration-perception. We used ANOVA to compare imaging measures and Spearman-correlation (r) to explore association between DTI and clinical measures. Statistics with p-values<0.05 were reported as significant. RESULTS: We detected: smaller CCA in NMOSD than HCs (mean=75.6 mm²[±11.4] vs. 85.8[±11.4]) and in MS than HCs (76.5mm²[±11] vs. 85.8[±11.4]), with no significant difference between patient groups; CCA reduced with longer disease-duration (r=-0.58) in NMOSD, and with worse disability (9-HPT test r=-0.51, handgrip-strength r=0.47) in MS. Compared to HCs, NMOSD patients showed reduced FA in GM and posterior-WM; higher RD in posterior-WM and AD in lateral-WM. MS patients had lower FA in the lateral-WM than HC. No difference in diffusion measures between patient groups was seen. In NMOSD, FA and RD of the posterior-WM were associated with worse vibration-perception (r=-0.63 and 0.52, respectively). CONCLUSION: Pathological involvement of spinal cord, as reflected by DTI, does not differ between NMOSD and MS. In NMOSD patients diffusion abnormalities in the posterior-WM may contribute to physical disability.Disclosure: Dr. Cortese has nothing to disclose. Dr. Magnollay has nothing to disclose. Dr. De Angelis has nothing to disclose. Dr. Eshaghi has nothing to disclose. Dr. Grussu has nothing to disclose. Dr. Prados has nothing to disclose. Dr. Ourselin has nothing to disclose. Dr. Yiannakas has nothing to disclose. Dr. Distaso has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Gandini Wheeler-Kingshott has nothing to disclose. Dr. Ciccarelli has received personal compensation for activities with Novartis, Biogen and GE as a consultant.Tuesday, April 19 2016, 8:30 am-7:00 pm