RT期刊文章SR电子T1延长母乳喂养婴儿减少未来Pediatric-Onset多发性硬化的风险:一项病例对照研究(P1.377)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P1.377 VO 86是16补充A1詹姆斯Brenton A1 Myla高盛年2016 UL http://n.首页neurology.org/content/86/16_Supplement/P1.377.abstract AB目的:母乳喂养的主要目的是分析协会历史阶段的风险在未来发展中Pediatric-Onset多发性硬化症(MS)。背景:是一种炎症,女士的中枢神经系统自身免疫性疾病表现在童年。的风险pediatric-onset女士(盐)是受到环境和遗传因素的影响。婴儿母乳喂养的历史保护出现在一些儿童自身免疫性疾病,但其影响在女士的童年是未知的风险。方法:26酸盐的生母病人,弗吉尼亚大学的儿科脱髓鞘疾病诊所,被要求完成一份调查问卷在这个问题上的历史和母乳喂养期间除了各种人口因素。组成的对照组39健康患者从大学的儿科头痛诊所诊断为偏头痛(和正常的大脑核磁共振获得<入学前1年),被要求完成调查。结果:人口的年龄和性别组之间没有显著差异。诞生历史有关的因素(交付方法、胎龄、出生体重),童年因素(兄弟姐妹、托儿所和在家教育的历史),和社会因素(保险类型,地理位置在生命的头15年)组之间没有显著差异。母乳喂养史(34.6 [percnt]病例;71.8 [percnt]控制)显著不同组(p = 0.003)。 In breastfed subjects, the duration of breastfeeding was also significantly different (cases: mean of 3.4 weeks; controls: mean of 28.8 weeks; p<0.0001). Multivariable logistic analysis demonstrated a significant positive association between lack of prolonged (< 4 months) breastfeeding and the development of POMS (OR 2.2; 95[percnt] CI 1.23-3.93). Conclusions: Preliminary analysis of our data demonstrates that infant breastfeeding for less than 4 months’ duration is associated with a two-fold increase in odds of future POMS diagnosis. Disclosure: Dr. Brenton has nothing to disclose. Dr. Goldman has received personal compensation for activities with Evidera, Genyzme, Novartis, Biogen, and Acorda. Dr. Goldman has received research support from Biogen Idec and Novartis.Saturday, April 16 2016, 8:30 am-7:00 pm