@article {MandelliP4.031作者={玛丽亚·路易萨铜质把手和爱德华·Vilaplana H。伊莎贝尔哈伯德和杰西布朗和米格尔桑托斯和理查德Binney则和Suneth Attygalle和玛雅亨利和罗兰·亨利和霍华德·罗森和布鲁斯·米勒和威廉·斯利和玛丽亚Gorno Tempini}, title ={纵向发展的萎缩Non-Fluent原发性进行性失语遵循功能/结构演讲汽车网络(P4.031)},体积={86}={16}补充数量,elocation-id = {P4.031} ={2016},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们假设毒性蛋白Non-Fluent / agrammatic变体原发性进行性失语(nfvPPA)将从早期传播transynaptically中心语言网络中连接的地区造成的发展随着时间的推移萎缩。首页据我们所知,没有纵向研究证实了这个假设。背景:功能性神经退化的内在连接网络帮助预测在不同疾病的显示模式萎缩镜子健康功能的网络体系结构。网络语言是nfvPPA容易萎缩,这通常是与病理有关。设计/方法:早期的震中是定义在一组早期nfvPPA (n = 10)的分布形态测量学(VBM)分析。从这个区域我们推导出实用言语/语言连接网络的健康对照组。然后我们确定底层与扩散tractography白质纤维。纵向灰质(GM)和白质(WM)变化进行评估34 nfvPPA VBM纵向分析。最后我们进行体积的变化之间的相关性分析病人和健康网络的力量。 Results: From the epicenter in the inferior frontal gyrus (IFG), the functional connectivity network in healthy controls comprises known areas involved in the speech/language function. Tractography delineated the WM pathways between the same regions. Significant longitudinal GM change was found in the left language-related regions and in the right IFG and precentral gyrus and the longitudinal WM change in the correspondent underlying regions. Significant correlations were found between GM changes in patients and the functional connectivity language network and between WM changes and fractional anisotropy along the language tracks. Conclusion: These findings suggest that the pattern of longitudinal progression of atrophy in nfvPPA reflects the anatomy of language functional network and support the hypothesis that the spread of degeneration occurs not only by contiguity but also following specific anatomical and functional network architectures.Disclosure: Dr. Mandelli has nothing to disclose. Dr. Vilaplana has nothing to disclose. Dr. Hubbard has nothing to disclose. Dr. Brown has nothing to disclose. Dr. Santos has nothing to disclose. Dr. Binney has nothing to disclose. Dr. Attygalle has nothing to disclose. Dr. Henry has nothing to disclose. Dr. Henry has received personal compensation for activities with StemCells, Inc. and Novartis. Dr. Rosen has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Seeley has received personal compensation for activities with Biogen Idec. as a consultant. Dr. Gorno Tempini has received personal compensation in an editorial capacity for Co-Editor, Neuroimage Clinical.Tuesday, April 19 2016, 8:30 am-7:00 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/86/16_Supplement/P4.031}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }