@article {XiaP4.180作者= {Zongqi夏和桑娅斯蒂尔Anshika问题和琼Ohayon Lori Chibnik和艾琳Cortese菲利普De Jager和丹尼尔帝国},title ={调查早期影像学和生物一级亲属发生前症状多发性硬化症的证据(P4.180)},体积={86}={16}补充数量,elocation-id = {P4.180} ={2016},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:评估脑磁共振成像(MRI)的患病率和微妙的临床异常发生前症状符合脱髓鞘和轴突丧失主题多发性硬化症(MS)的风险。首页背景:亚临床炎症性脱髓鞘和神经退行性变的女士可能出现症状之前方法:多发性硬化症(宝石)的基因和环境是女士一级亲属的前瞻性队列研究,探讨危险因素和事件的序列导致发病。主题18-50年招生,他们的风险敏感性女士使用加权评估遗传和环境风险评分(蒙古包)。受试者在顶部和底部的10 [percnt]蒙古包分布进行了脑磁共振3-tesla钆和光学相干断层扫描以及定量临床测量(包括标准神经系统残疾量表、振动感知128赫兹和Rydel音叉和第二电磁共振器设备)。逻辑回归和通用估计方程建模蒙古包群风险之间的关系和二进制和持续的结果,分别。结果:本研究包括100例高危(n = 98 (percnt)女性)和低风险(n = 59岁42 (percnt)女性)子组,平均年龄为35.1岁。鉴于高和低风险组之间的不平等的性别分布,我们限制分析女性(n = 65)。五个科目(8 [percnt])遇到T2-hyperintense病变的主要结果符合2010核磁共振在空间传播的标准(四个高危人群;p = 0.2)。Leptomeningeal对比度增强检测四个学科(6 [percnt]),三个高危组。 Interestingly, high-risk subjects exhibited diminished vibration sensitivity in lower extremities, detected by all three vibratory tests, most significantly Vibratron II (p=6.1x10-5). Conclusions: Presymptomatic family members at high risk for MS manifest diminished vibration sensitivity. If validated, this may constitute evidence of early subclinical demyelination and/or neurodegeneration.Disclosure: Dr. Xia has nothing to disclose. Dr. Steele has nothing to disclose. Dr. Bakshi has nothing to disclose. Dr. Ohayon has nothing to disclose. Dr. Chibnik has nothing to disclose. Dr. Cortese has nothing to disclose. Dr. De Jager has received research support from Biogen Idec and Genzyme. Dr. Reich has received research support from Vertex Pharmaceuticals.Tuesday, April 19 2016, 8:30 am-7:00 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/86/16_Supplement/P4.180}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }