TY - T1的盛行的伴随疾病在病理证实阿尔茨海默病大脑在加拿大地区生物神经学(P6.221) JF -乔-神经学六世- 86 - 16补充SP - P6.221盟-迈克尔Marnane盟Shervin Mortazavi AU -李昕盟安琪拉金盟-康纳·凯勒AU -伊恩R.A. Mac首页kenzie盟成立Ging-Yuek Y1 - 2016/04/05 UR - //www.ez-admanager.com/content/86/16_Supplement/P6.221.abstract N2 -目的:定义阶段的患病率和与年龄和血管神经退化性疾病在病理证实阿尔茨海默病(AD)。背景最近的研究表明,co-existent神经退行性和/或血管病理是广告的规则,而不是例外。底层驱动程序的伴随疾病广告仍不清楚。方法本研究是由省级神经病理学转诊中心在温哥华,不列颠哥伦比亚省。小学和贡献的病原学诊断所有的大脑进行解剖都记录了一个经验丰富的神经病理学家的身份发言在1997年12月至2015年1月之间。共识neuropathologic标准使用,可用来定义广告,脑血管病(CVD)、路易体痴呆与下文),额颞叶大叶性变性(FTLD) Corticobasal变性(CBD),进行性核上的麻痹(PSP)和海马硬化(HS)。结果147例NIA /里根被确定广告被确定。广告共存与CVD(定义为中度或严重的动脉硬化或中度或重度脑淀粉样血管病或出现腔隙性脑梗死或大型artery-related脑梗死或出血性脑梗塞)在78.9 [percnt](116/147),中度或重度脑淀粉样血管病在39.5 [percnt](58/147),中度或重度动脉硬化在70.7 [percnt](104/147),下文在26.5 [percnt] (39/147), FTLD 2 [percnt] (3/147), CBD 2 [percnt](3/147),在0.7 PSP percnt(1/147),和海关6.8 [percnt]。27.2 [percnt](40/147)有2个或更多的病态除了广告。那些额外的病态的人比情况下单独使用广告(77.7 (9.8 + / - SD)年和70.0(+ / - 8.4)岁,p = 0.002)。 Older age was associated with increasing number of additional pathologies (spearman rho= 0.29, p=0.004). Conclusion Multi-morbidity is a common finding in an autopsy cohort of pathologically confirmed AD and associated with advancing age. This could have implications for future efforts to identify effective therapeutic strategies in dementia- favouring approaches that can target multiple age-related pathologies simultaneously.Disclosure: Dr. Marnane has nothing to disclose. Dr. Mortazavi has nothing to disclose. Dr. Li has nothing to disclose. Dr. Kim has nothing to disclose. Dr. Connor has nothing to disclose. Dr. Mackenzie has nothing to disclose. Dr. Hsiung has received research support from Baxter, Bristol-Myers Squibb, TauRx, Elan, and GlaxoSmithKline.Thursday, April 21 2016, 8:30 am-5:30 pm ER -