PT -期刊文章盟-珍妮弗Whitwell盟Stephen Weigand AU -约瑟夫·达菲盟Edythe链非盟-玛丽Machulda AU -希瑟·克拉克盟-马修Senjem AU -克利福德杰克盟-基思·约瑟夫TI -语法缺失预测下降,言语失用症和帕金森症Agrammatic原发性进行性失语(P4.030) DP - 2016年4月05 TA -神经病学PG - P4.030 VI - 86 IP - 16补充4099 - //www.ez-admanager.com/content/86/16_Supplement/P4.030.short 4100 - //www.ez-admanager.com/content/86/16_Supplement/P4.030.full所首页以Neurology2016 4月05;86 AB -目的:确定基线神经成像预测未来利率下降的临床agrammatic原发性进行性失语患者(agPPA)或进步言语失用症(有关)。背景:语法缺失和言语失用症agPPA和有关的特征。在这些特性是可变的,下降的速度预测困难。这些患者也常常出现震颤麻痹,迅速发展为帕金森症的一个子集。生物学标志物,可以帮助预测率下降的临床改善预后估计至关重要。设计/方法:38 agPPA或有关患者接受基线语言和神经系统评估,两年后和磁共振成像,然后返回。语法缺失测量使用西方失语症电池失语商(WAB-AQ),言语失用症用言语失用症的测量评定量表(曾经)和帕金森症测量使用统一帕金森病评定Scale-3 (UPDRS-3)。基线区域灰质体积计算。混合效应模型被用来确定基线卷的程度预测未来利率下降的临床措施。 RESULTS: Mean annual rate of decline was -4 points (95[percnt] CI: -14 to 5) for WAB-AQ, 3 points (-3 to 9) for ASRS and 8 points (-9 to 26) for UPDRS-3. Small baseline volumes of supplementary motor area, premotor, precentral and paracentral cortex were associated with increased rates of decline on the UPDRS-3. Large volumes (i.e. relative sparing) of Broca's area was associated with increased rates of decline on the ASRS and large paracentral volumes were associated with increased rates of decline on the WAB-AQ. CONCLUSIONS: Neuroimaging measures have potential to be useful biomarkers of future clinical decline in these patients, particularly with atrophic premotor and motor regions predicting decline in Parkinsonism. Study supported by: R01-DC12519Disclosure: Dr. Whitwell has nothing to disclose. Dr. Weigand has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. Strand has nothing to disclose. Dr. Machulda has nothing to disclose. Dr. Clark has nothing to disclose. Dr. Senjem has nothing to disclose. Dr. Jack has received personal compensation for activities with Janssen Research & Development, LLC by providing consulting services. Dr. Jack has received research support from the National Institutes of Health (R01-AG011378, RO1-AG041851, RO1-AG037551. Dr. Josephs has nothing to disclose.Tuesday, April 19 2016, 8:30 am-7:00 pm