TY - T1的核磁共振成像和病理相关性研究阿特拉斯阿尔茨海默氏症(S39.008) JF -神经学乔-神经学六世- 86 - 16补充SP - S39.008盟Mekala喇曼非盟-克里斯托弗•施瓦兹盟梅丽莎·默里盟- Va首页l劳盟-丹尼斯·迪克森盟-克利福德杰克盟Kejal Kantarci Y1 - 2016/04/05 UR - //www.ez-admanager.com/content/86/16_Supplement/S39.008.abstract N2 -目标:我们的目标是开发一个大脑核磁共振图谱代表8皮质区域定期取样的尸检病理诊断阿尔茨海默病(AD)。背景:病理诊断是黄金标准在评估成像标记为特定的病理生理的开发流程。脑部核磁共振图谱代表autopsy-sampled组织可以利用直接成像和病理结果之间的比较。方法:受试者(n = 22)与一系列广告,microinfarct和路易体病理体内3 t MRI是包括在内。组织学幻灯片从8皮质区域抽样从左半球尸检病理学家三个引导阿特拉斯的定位感兴趣的区域(roi)每个主题的体内3 d t1加权磁共振成像。每门学科的roi的原生T1空间形象被注册到一个共同的模板生成从202老年人。由此产生的ROI包括组织的体积采样的病理学家。对象的一个子集(n = 4) C-11匹兹堡化合物b (PiB-PET)淀粉样蛋白成像获得前2年内死亡。β-amyloid密度从解剖量化采样区域4受试者使用专门设计的颜色反褶积透视仪算法来检测密度β-amyloid(33.1.1)应用。平均标准摄入值比(SUVR)每个ROI的计算加以登记后PiB-PET图像到核磁共振图谱模板。 Results: We found a significant association between β-amyloid plaque density in 8 ROIs of the 4 subjects (total ROI n=32) and median PiB SUVR (r^2=0.64; p<0.0001). Conclusions:In a cortical brain atlas developed for imaging and pathologic correlation studies, we demonstrated that in vivo amyloid burden measured in the atlas ROIs on amyloid PET is strongly correlated with β-amyloid density measured on histology. This atlas can be used in imaging and pathologic correlation studies.Disclosure: Dr. Raman has nothing to disclose. Dr. Schwarz has nothing to disclose. Dr. Murray has nothing to disclose. Dr. Lowe has received personal compensation for activities with Bayer Pharmaceuticals as a consultant. Dr. Dickson has nothing to disclose. Dr. Jack has received personal compensation for activities with Janssen Research & Development, LLC by providing consulting services. Dr. Jack has received research support from the National Institutes of Health (R01-AG011378, RO1-AG041851, RO1-AG037551. Dr. Kantarci has received personal compensation for activities with Takeda and Novartis.Wednesday, April 20 2016, 1:00 pm-3:00 pm ER -