% 0期刊文章%布莱恩Appavu %一个约翰Condie丽莎Vanatta % % Randa Jarrar约翰·克里根% % T生酮饮食治疗小儿Super-Refractory癫痫持续状态(P4.215) % D J神经病学2016% % P P4.215 X % V % 86% N 16补充目的:我们描述10儿科患者Super-Refractory癫痫持续状态(SRSE)接受生酮饮食(首页KD)治疗。背景:Super-Refractory癫痫持续状态(SRSE)被定义为癫痫持续状态,持续至少24小时后开始麻醉药物和包括癫痫持续状态的情况反复出现减少麻醉。生酮饮食(KD)是一种高脂肪、低碳水化合物、足够的蛋白质的饮食已被证明是一种有效的饮食治疗儿童难治性癫痫。方法:在凤凰IRB回顾性审查批准儿童医院患者SRSE接受KD疗法从2011年到2015年。数据包括年龄、性别、病因的癫痫,并发治疗,和结果。结果:与SRSE十个孩子,- 18岁,被确定。4/10的患者免疫介导脑炎。其他病因包括Lennox Gastaut综合症,non-ketotic hyperglycinemia, PCDH19和GABRG2基因癫痫、新难治性癫痫持续状态发作,发热性感染相关性癫痫综合征。4/10的患者的脑电图特点建议焦SRSE,提出广义SRSE 6/10。平均住院时间是61天,ICU中位数长度是27天。抗癫痫药物的平均次数KD启动3.0药物之前,和KD治疗后中值为3.5的药物。 Median duration of SRSE prior to KD was 18 days. 9/10 patients had resolution of SRSE in a median of 7 days after KD initiation. 8/9 patients with SRSE resolution were weaned off anesthesia within 15 days of KD initiation, and within 1 day of achieving ketonuria. 1/10 patients experienced side effects on KD requiring supplementation. Conclusions: In our experience, most patients achieved resolution of SRSE with KD therapy, and resolution occurred within days of initiation. KD was tolerated with little side effects, suggesting that it is a safe treatment for children with SRSE.Disclosure: Dr. Appavu has nothing to disclose. Dr. Vanatta has nothing to disclose. Dr. Condie has nothing to disclose. Dr. Kerrigan has nothing to disclose. Dr. Jarrar has nothing to disclose.Tuesday, April 19 2016, 8:30 am-7:00 pm %U

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