RT期刊文章SR电子T1小脑灰质过剩和亨廷顿氏舞蹈症萎缩:一个分布形态测量学研究(P1.059)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P1.059 VO 86是16补充A1 Paula代理A1瑞秋吉马良斯A1卡米拉Piccinin A1 Lui首页za Piovesana A1 Lidiane Campos A1 Giordanna ibsen Pinheiro A1玛丽亚克里斯蒂娜Arci桑托斯A1拉里萨Vilany A1奥古斯托Amato-Filho A1费尔南多Cendes A1 Iscia Lopes-Cendes A1 Anelyssa D 'Abreu年2016 UL //www.ez-admanager.com/content/86/16_Supplement/P1.059.abstract AB目的:我们研究的目的是详细的小脑灰质(GM)改变高清使用该工具“空间无偏模板阿特拉斯”(套装)基于体素的形态测量学(VBM)磁共振成像(MRI)。背景:在过去的年里,小脑在神经退行性疾病的作用已被广泛研究。然而,很少有研究相关的小脑和亨廷顿氏舞蹈症(HD)。这不仅是由于小脑贡献在电动机细化,但主要是由非功能的发现。方法:我们比较匹配的26例患者在性别和年龄26控制。他们接受了神经(统一亨廷顿氏舞蹈症量表- UHDRS)和认知(蒙特利尔认知评估-上海)评估。适合用于分析通用改变。我们创建了一个两个示例测试分析通用汽车两组之间的差异和另一个关联的小脑通用改变UHDRS(情绪和运动)和MOCA分数,纠正了年龄,cytosine-adenine-guanine (CAG)重复和疾病持续时间。结果:诉讼结果分为一般:通用过剩和萎缩与控制相比,分别位于前和postero-superior小脑叶;和具体:UHDRS(情绪和运动)和MOCA分数。 Higher GM density in the postero-superior lobe correlated with mood symptoms. Worse motor function and better cognitive function correlated with GM changes in the posterior cerebellum (p<0.001 and k>100 voxels). Conclusions: The listed areas are responsible for sensorimotor integration, motor planning, visuospatial function and emotional processing. We believe these findings may contribute to a better understanding of the neuropathological process of HD.Disclosure: Dr. Azevedo has nothing to disclose. Dr. Guimarães has nothing to disclose. Dr. Piccinin has nothing to disclose. Dr. Piovesana has nothing to disclose. Dr. Campos has nothing to disclose. Dr. Pinheiro has nothing to disclose. Dr. Arci Santos has nothing to disclose. Dr. Vilany has nothing to disclose. Dr. Amato-Filho has nothing to disclose. Dr. Cendes has nothing to disclose. Dr. Lopes-Cendes has nothing to disclose. Dr. d'Abreu has nothing to disclose.Saturday, April 16 2016, 8:30 am-7:00 pm