@article {PaseS32.006作者={马修Pase Alexa Beiser和丹尼尔Enserro瓦妮莎Xanthakis雨果·哈维尔Aparicio和克劳迪娅Satizabal Jayandra Himali Vasan卡洛斯·凯斯和拉马钱德兰和Charles DeCarli Sudha Seshadri}, title ={坚持理想的心血管健康指南可防止血管脑损伤,痴呆和认知能力下降(S32.006)},体积={86}={16}补充数量,elocation-id = {S32.006} ={2016},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:我们的目的是探讨未来理想的心血管健康协会(CVH)与血管脑损伤,包括10年期中风和痴呆的风险事件,以及认知能力下降和MRI脑萎缩,测量了大约7年。首页背景:血管危险因素导致脑血管疾病日益增长的负担,认知障碍和痴呆。美国心脏协会{\ textquoteright}年代(啊哈)Ideal-CVH指数已经开发成一个简单的工具来促进心血管健康,然而其与脑萎缩和老年痴呆症协会仍然是未经检验的。设计/方法:我们对2750名中风,dementia-free弗雷明汉心脏研究的后代群体参与者(平均年龄62 {\ textpm} 9 y;45 (percnt)男性)。Ideal-CVH量化7分制有一点授予以下;不吸烟的状况,理想的身体质量指数,有规律的体育锻炼,健康的饮食,以及最佳血压、胆固醇、空腹血糖。最近(基线)和远程(6.9年前)Ideal-CVH分数。结果:有87、84、64和14事件的中风,全因痴呆、阿尔茨海默{\ textquoteright}年代分别疾病和血管性痴呆。最近Ideal-CVH与中风有关(人力资源0 {\ textperiodcentered} 80、95 (percnt) CI 67 - 0 0 {\ textperiodcentered} {\ textperiodcentered} 95),血管性痴呆(HR 0 {\ textperiodcentered} 49岁,95 [percnt] CI 0 {\ textperiodcentered} 30-0 {\ textperiodcentered} 81),额叶脑萎缩(β0 {\ textperiodcentered} 31日SE 0 {\ textperiodcentered} 10, 003 p = {\ textperiodcentered}),和认知下降任务测量视觉记忆和推理(β0 {\ textperiodcentered} 02, SE 0 {\ textperiodcentered} 01, p \ < {\ textperiodcentered} 04)。 In addition to predicting stroke, vascular dementia, whole brain atrophy, and cognitive decline, remote Ideal-CVH was associated with the incidence of all-cause dementia (HR 0{\textperiodcentered}80, 95[percnt] CI 0{\textperiodcentered}67-0{\textperiodcentered}97) and Alzheimer{\textquoteright}s disease (HR 0{\textperiodcentered}79, 95[percnt] CI 0{\textperiodcentered}64-0{\textperiodcentered}98). CONCLUSIONS Adherence to the AHA{\textquoteright}s Ideal-CVH factors and behaviours, particularly in midlife, may protect against vascular brain injury and dementia. Study Supported by: NIH; NHLBI; NIA; NINDS; NHMRC.Disclosure: Dr. Pase has nothing to disclose. Dr. Beiser has nothing to disclose. Dr. Enserro has nothing to disclose. Dr. Xanthakis has nothing to disclose. Dr. Aparicio has nothing to disclose. Dr. Satizabal has nothing to disclose. Dr. Himali has nothing to disclose. Dr. Kase has nothing to disclose. Dr. Ramachandran has nothing to disclose. Dr. DeCarli has nothing to disclose. Dr. Seshadri has nothing to disclose.Tuesday, April 19 2016, 1:00 pm-3:00 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/86/16_Supplement/S32.006}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }