@article {MaggiP3.015作者= {Pietro美极和弗朗西斯科·Zellini亚历桑德罗·Barilaro和亚历山德罗Passeri卢卡Massacesi}, title ={可视化与多发性硬化病变的MRI:洞察焦病理学(P3.015)},体积={86}={16}补充数量,elocation-id = {P3.015} ={2016},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景:磁共振成像提供了体内见解焦女士病理学上不同的序列不同的底层生物现象很敏感。首页目的:分析新女士病变体积变化随着时间的推移,使用不同的核磁共振技术和提出一个MS病灶形成的模型。方法:患者RR (n = 12)随访女士每月在1.5 T MRI扫描仪。(Gd)钆增强病变的体积(n = 100, 16圈和84结节)是评估在天赋和T1w单一(T1wGdSD)和三(T1wGdTD)剂量的Gd。我们叫{\ textquotedblleft} {\ textquotedblright}峰值量,最高的一个记录在每月跟进{\ textquotedblleft}天赋结果{\ textquotedblright}卷结束后6个月T1w增强。动时间进程分析应用于天赋和T1wGd卷和病理生理动机两个随机行走动力学数学模型应用到天赋卷。结果:在急性期,天赋体积在高峰导致\ > T1wGdTD \ > T1wGdSD卷在高峰,显示类似的钟形的概要文件。天赋的结果数量总是\ < T1wGd卷在高峰。天赋卷结果来描述两个随机漫步曲线:发病迅速,具有类似形状相比T1wGd曲线和第二个开始在同一时间,但慢慢地增加和减少。结节性(R2 0.7 {\ textpm} 0.1)和环(R2 0.81 {\ textpm} 0.08)病变所描述的这个模型拟合质量高。 CONCLUSIONS: In the acute phase the pathologic substrate of the lesions is made of overlapping layers: a central {\textquotedblleft}core{\textquotedblright}, containing inflammation, blood brain barrier (BBB) disruption and irreversible tissue damage and an external {\textquotedblleft}penumbra{\textquotedblright}, with reversible BBB and tissue damage surrounded by water diffusing from the inner layers. This biological model was valid for both nodular and ring enhancing lesions suggesting a similar physiopathological substrate.Disclosure: Dr. Maggi has nothing to disclose. Dr. Zellini has nothing to disclose. Dr. Barilaro has nothing to disclose. Dr. Passeri has nothing to disclose. Dr. Massacesi has nothing to disclose.Monday, April 18 2016, 8:30 am-7:00 pm}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/86/16_Supplement/P3.015}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }