TY - T1的可视化与多发性硬化病变的MRI:洞察焦病理学(P3.015) JF -神经学乔-神经学六世- 86 - 16补充SP - P3.015盟Pietro美极AU -弗朗西斯科·Zellini盟亚历山德罗Barilaro AU -亚首页历山德罗Passeri盟卢卡Massacesi Y1 - 2016/04/05 UR - //www.ez-admanager.com/content/86/16_Supplement/P3.015.abstract N2 -背景:核磁共振成像焦女士病理学上提供了体内见解不同序列不同的底层生物现象很敏感。目的:分析新女士病变体积变化随着时间的推移,使用不同的核磁共振技术和提出一个MS病灶形成的模型。方法:患者RR (n = 12)随访女士每月在1.5 T MRI扫描仪。(Gd)钆增强病变的体积(n = 100, 16圈和84结节)是评估在天赋和T1w单一(T1wGdSD)和三(T1wGdTD)剂量的Gd。我们称为“峰值”体积,最高的一个记录在每月跟进“天赋的结果”卷结束后6个月T1w增强。动时间进程分析应用于天赋和T1wGd卷和病理生理动机两个随机行走动力学数学模型应用到天赋卷。结果:在急性期,天赋体积在高峰导致祝辞T1wGdTD是祝辞T1wGdSD卷在高峰,显示类似的钟形的概要文件。天赋的结果数量总是& lt;T1wGd卷在高峰。天赋卷结果来描述两个随机漫步曲线:发病迅速,具有类似形状相比T1wGd曲线和第二个开始在同一时间,但慢慢地增加和减少。 Both nodular (R2 0.7 ±0.1) and ring (R2 0.81 ±0.08) lesions were described by this model with high fitting quality. CONCLUSIONS: In the acute phase the pathologic substrate of the lesions is made of overlapping layers: a central “core”, containing inflammation, blood brain barrier (BBB) disruption and irreversible tissue damage and an external “penumbra”, with reversible BBB and tissue damage surrounded by water diffusing from the inner layers. This biological model was valid for both nodular and ring enhancing lesions suggesting a similar physiopathological substrate.Disclosure: Dr. Maggi has nothing to disclose. Dr. Zellini has nothing to disclose. Dr. Barilaro has nothing to disclose. Dr. Passeri has nothing to disclose. Dr. Massacesi has nothing to disclose.Monday, April 18 2016, 8:30 am-7:00 pm ER -